在非洲治疗抗药性的手术:系统性审查
Kwadwo Darko1, Pearl Ohenewaa Tenkorang2, Olivia Asiedu2
1Department of Neurosurgery, Korle Bu Teaching Hospital, Accra , Ghana.
Neurosurgery
|December 12, 2024
概括
手术在非洲是有效的,有80.6%的患者在手术后实现了无发作. 长期随访证实了持续的控制,突出的是手术.
科学领域:
- 神经学 神经学
- 神经外科 神经外科
- 公共卫生 公共卫生
背景情况:
- 影响全球数百万人,近三分之一的人患有耐药性 (DRE).
- DRE带来了重大挑战,往往需要手术干预才能有效管理.
- 非洲面临着巨大的病负担,这凸显了对可获得和有效治疗的需求.
研究的目的:
- 描述在非洲接受手术的DRE患者的人口特征.
- 检查整个非洲大陆的手术接入和用于DRE管理的策略.
- 评估手术在非洲人群中的疗效和结果.
主要方法:
- 在主要的科学数据库 (PubMed,Google Scholar,Embase,Web of Science) 中进行了系统审查.
- 该审查遵循了系统审查和元分析 (PRISMA) 的优先报告项目指南.
- 这项分析包括了9项涉及来自非洲6个国家的498名患者的研究.
主要成果:
- 患者的平均年龄为24.9岁,男性占主导地位 (53.4%).
- 焦点发作最常见 (73.1%),头部创伤是常见的风险因素 (33.1%).
- 叶切除术 (59.6%) 是主要的手术程序,在术后产生了80.6%的发作自由 (英格尔I类),在长期随访时维持在70.3%.
结论:
- 手术是非洲DRE的高效治疗方法.
- 手术干预提供了显著的长期益处,改善了控制和生活质量.
- 解决手术接入问题对于扩大这些改变生活的治疗方法在非洲至关重要.
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