准确的内肌心出血评估与快速,自由运行,心脏定量敏感度映射
Yuheng Huang1, Xingmin Guan1, Xinheng Zhang1
1From the Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, 116 N Robertson Blvd, Pacific Theatres Bldg, Ste 400, Los Angeles, CA 90048 (Y.H., L.T.H., H.L.L., D.L., H. Han, A.G.C., H.J.Y.); Krannert Cardiovascular Research Center, Indiana University School of Medicine, Indianapolis, Ind (Y.H., X.G., X.Z., G.Y., G.A., S.F.C., K.P.V., B.S., D.P.S., K.Y., R.D.); Departments of Bioengineering (Y.H., X.Z., A.G.C.) and Statistics (H. Ho), University of California Los Angeles, Los Angeles, Calif; Academia Sinica, Institute of Statistical Science, Nankang, Taipei, Taiwan (H. Ho); Department of Surgery, Division of Neurosurgery, Mackay Memorial Hospital, Taipei, Taiwan (L.T.H.); Department of Medical Imaging, National Cheng Kung University Hospital, Tainan, Taiwan (H.Y.L.); Siemens Medical Solutions USA, Malvern, Pa (X.B., F.H.); and Department of Radiological Sciences, University of California Los Angeles David Geffen School of Medicine, Los Angeles, Calif (A.G.C.).
高动态范围定量敏感度映射 (HDR-QSM) 准确检测心脏内出血 (IMH) 并量化犬类模型中的铁. 这种快速的心脏MRI技术比传统的IMH评估方法提供了更好的图像质量和性能.
科学领域:
- 心血管磁共振成像 - 心血管磁共振成像
- 量化敏感性映射 量化敏感性映射
- 生物标志物量化量化
背景情况:
- 心脏内出血 (IMH) 是心肌梗塞后的一个关键并发症.
- 准确检测和量化IMH及其铁含量对于患者管理至关重要.
- 传统的IMH评估MRI技术在图像质量和量化准确性方面存在局限性.
研究的目的:
- 评估一种新的高动态范围定量敏感度映射 (HDR-QSM) 心脏MRI技术的性能.
- 评估HDR-QSM检测IMH和量化心脏内铁含量的能力.
- 为了将HDR-QSM与幻影和狗模型中的传统R2*映射进行比较.
主要方法:
- 为IMH评估开发和应用一个自由运行的全心HDR-QSM技术.
- 在校准的铁幻体和14个诱导IMH的雌性犬模型中进行评估.
- 将HDR-QSM与R2*地图进行比较,使用ex vivo成像作为参考标准.
主要成果:
- 幻影研究显示铁度和QSM值之间存在强烈的线性相关性 (R 2=0.98),证实了精确的量化和工件减轻.
- 与R2* (P <.001) 相比,体内HDR-QSM显示出优越的图像质量和敏感性均性.
- 在IMH检测 (AUC,0.96对0.75;P<.001) 和铁量化 (R2,0.71对0.14) 中,HDR-QSM的表现优于R2*.
结论:
- 快速,自由运行的心脏HDR-QSM技术准确地检测IMH并量化心内铁.
- 这种方法可以在5分钟内覆盖整个心脏,而不需要屏息.
- 在临床实践中,HDR-QSM代表了IMH评估的有希望的进步.
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