驴奶对大鼠中乙醇诱导的胃的保护作用
Masoud Sami1, Shahrzad Azizi2, Reza Kheirandish2
1Department of Food Science and Technology, School of Nutrition and Food Science, Nutrition and Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Veterinary medicine and science
|December 12, 2024
概括
驴奶在老鼠中显示出对乙醇诱导的胃的胃保护作用. 用驴奶进行预处理显著降低了的严重程度,甲水平,并增加了谷氨,表明抗氧化性质.
科学领域:
- 胃肠病学 胃肠病学
- 药理学 药理学是指药理学的学科.
- 自然产品研究 自然产品研究
背景情况:
- 胃 (GU) 是由于粘膜防御和攻击因素之间的不平衡造成的.
- 在动物模型中,乙醇诱导的胃模仿了人类病理生理学.
- 对于治疗的自然产品有较少副作用的需求.
研究的目的:
- 调查驴奶对大鼠乙醇诱导的胃的胃保护潜力.
- 在胃的背景下评估驴奶的抗氧化作用.
主要方法:
- 雄性Wistar大鼠被分为四个组:对照组,驴奶和ranitidine.
- 在乙醇诱导胃之前,驴奶和拉尼蒂丁被口服10天.
- 对胃组织进行了分析,以检测分数,甲 (MDA) 和谷氨 (GSH) 水平.
主要成果:
- 驴奶预处理显著降低了乙醇诱导的胃损伤的严重程度.
- 观察到得分和MDA水平显著降低.
- 在胃组织中增加的GSH水平表明具有保护性的抗氧化作用.
结论:
- 驴奶对乙醇诱导的胃潰瘍具有显著的胃保护和抗氧化作用.
- 这些发现支持使用驴奶作为胃的潜在天然治疗剂.
- 进一步的研究可以探索导致这些影响的特定化合物和机制.
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