在牛皮中调查临床和亚临床损伤
Belgin Kucukyangoz1, Mualla Polat2, Mustafa Kucukyangoz3
1Department of Dermatology, Necip Fazil City Hospital, Kahramanmaras, Turkey.
Archives of dermatological research
|December 12, 2024
概括
牛皮病 (PV) 患者表现出蛋白尿增加,表明亚临床损伤. 早期监测蛋白尿和特定生物标志物可以帮助检测PV患者的问题.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 皮肤病学 皮肤病学
- 系统性炎症性疾病系统性炎症性疾病
背景情况:
- 牛皮是一种全身性炎症性疾病,报告的参与度可变.
- 虽然研究了牛皮的慢性损伤,但亚临床损伤需要进一步调查.
研究的目的:
- 在患有牛皮病 (PV) 的患者中前性评估临床和亚临床损伤.
主要方法:
- 招募了44名PV患者和44名健康对照.
- 测量了血清尿素,肌素,GFR,尿液分析,尿液显微镜和亚临床脏损伤标志物 (白蛋白尿,蛋白尿,UKIM-1/肌素,uNGAL/肌素,尿路波多卡力辛/肌素).
主要成果:
- 在PV患者中,蛋白尿的水平显著更高 (p=0.021).
- 在PV患者中发现蛋白尿和UKIM-1/肌素,uNGAL/肌素和专尿之间的积极相关性.
- 没有检测到临床损伤,但高蛋白尿症表明亚临床损伤.
结论:
- 牛皮似乎不会导致临床损伤.
- 增加的蛋白尿表明PV患者的亚临床损伤.
- 监测蛋白尿和特定生物标志物 (uKIM-1/肌素,uNGAL/肌素,白尿) 可能能够在PV中早期检测损伤.
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