艾滋病的发病率和死亡率:一项为期42年的基于人口的全国性研究
Lotte Sahin Levison1, Jakob Udby Blicher2, Henning Andersen2
1Department of Neurology, Aarhus University Hospital, Aarhus, Denmark. lotlev@rm.dk.
Journal of neurology
|December 12, 2024
概括
从1980年到2021年,丹麦的肌缩侧面硬化症 (ALS) 发病率和死亡率翻了三倍. 这种增加与男性性别和年龄较大有关,预计会有更多的老年患者.
科学领域:
- 神经学 神经学
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 最近的研究表明,肌缩侧面硬化症 (ALS) 的发病率和死亡率正在上升.
- 这种增加的原因,无论是改善诊断还是真正的增加,仍然不清楚.
- 这项研究调查了丹麦42年的ALS趋势.
研究的目的:
- 检查丹麦肌缩侧面硬化症 (ALS) 发病率和死亡率的趋势.
- 确定观察到的增加是由于病例确诊的改善,还是由于ALS的真正增加.
- 分析与ALS发病率和死亡率相关的人口因素.
主要方法:
- 在18岁以上的个人中首次诊断ALS的个体级数据来自丹麦神经病学部门.
- 发病率 (IR) 和死亡率 (MR) 计算为1980-2021年期间.
- 数据按性别和诊断时的年龄分层.
主要成果:
- 总共有5943名ALS患者和5069例死亡被确定.
- 整体ALS发病率为每10万人/年3.4人.
- 从1980-1983年到2018-2021年,ALS发病率增加了2.8倍,死亡率也在上升,与男性性别和年龄相联系.
结论:
- 1980年至2021年期间,丹麦的肌缩性侧面硬化症发病率和死亡率翻了三倍.
- 风险增加与男性性别和诊断时的更高年龄有关.
- 由于人口老龄化,预计老年ALS患者的数量将大幅增加.
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