肠道微生物群和艾滋病毒感染者的衰老 - - 我们所知道和不知道的
S M Shamsul Islam1, Shalini Singh1, Ali Keshavarzian2,3
1Northwestern University, 300 E Superior St, Chicago, IL, 60611, USA.
Current HIV/AIDS reports
|December 12, 2024
概括
艾滋病毒感染者因肠道屏障损伤和微生物失衡而经历过早衰,即使有有效的抗逆转录病毒疗法 (ART). 这些因素驱动慢性炎症,导致与年龄相关的疾病.
科学领域:
- 胃肠病学 胃肠病学
- 免疫学 免疫学 免疫学
- 传染性疾病 传染性疾病
背景情况:
- 艾滋病毒感染者 (PWH) 呈现加速衰老和与年龄有关的疾病风险增加,尽管通过抗逆转录病毒疗法 (ART) 抑制病毒.
- 胃肠道 (GI) 系统问题,包括肠道屏障功能受损和肠道微生物失调症,与这些并发症有关.
研究的目的:
- 调查肠道干扰的作用,特别是肠道屏障完整性和微生物失生症,在PWH中导致过早衰老和并发病的作用.
- 识别知识差距并探索针对肠道微生物群的治疗策略,以缓解炎症和延迟与年龄相关的病理.
主要方法:
- 本综述综合了当前关于艾滋病毒对肠道屏障和微生物群的影响的研究.
- 对检查肠道健康,炎症,细胞应激和PWH中衰老之间的关系的研究进行分析.
主要成果:
- 艾滋病毒感染损害了肠道上皮屏障,增加了透性和微生物转移,导致慢性炎症和细胞应激.
- 治疗不完全恢复肠道屏障的完整性,导致持续的炎症.
- 与艾滋病毒相关的微生物失调促进促炎性细菌,加剧炎症和组织损伤,可能导致过早衰老.
结论:
- 肠道屏障功能障碍和微生物失调是导致PWH慢性炎症,细胞应激和过早衰老的关键因素.
- 准肠道微生物群是一个有希望的治疗途径,可以减少PWH的炎症和减缓与年龄有关的疾病.
更多相关视频
05:53Measuring Frailty in HIV-infected Individuals. Identification of Frail Patients is the First Step to Amelioration and Reversal of Frailty
Published on: July 24, 2013
16.6K
07:27Exergaming in Older People Living with HIV Improves Balance, Mobility and Ameliorates Some Aspects of Frailty
Published on: October 6, 2016
10.2K
相关概念视频
01:26Factors Affecting the Risk of Infection
11.4K
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
11.4K
01:29Pulmonary Tuberculosis I
220
Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
220
01:23Anatomy of the Intestines
71.3K
Although digestion of proteins, carbohydrates, and lipids may begin in the stomach, it is completed in the intestine. The absorption of nutrients, water, and electrolytes from food and drink also occurs in the intestine. The intestines can be divided into two structurally distinct organs—the small and large intestines.
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
71.3K
01:26Aging
37
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
37
01:37Mitochondria
10.9K
Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...
10.9K
01:29Bacterial Flora of the Large Intestine
378
The gut microbiome is formed by a vast and diverse community of bacteria that colonizes our large intestine. These bacteria start residing in the gut from birth and continue diversifying throughout life, influenced by factors such as diet, lifestyle, and stress. The gut bacterial community also includes bacteria from food and those that enter the colon through the anus.
The normal gut flora of the colon plays a critical role in generating essential vitamins such as vitamins K, B5, and B7.
The normal gut flora of the colon plays a critical role in generating essential vitamins such as vitamins K, B5, and B7.
378