低磁血在原发性甲状腺功能障碍症中的重要性:一项土耳其全国性回顾性队列研究
Bekir Ucan1, Naim Ata2, Muhammed Kizilgul3
1Department of Endocrinology and Metabolism, Etlik City Hospital, Varlık Mahallesi, Halil Sezai Erkut Caddesi, 06170, Ankara, Türkiye. uzm.dr.bekir@hotmail.com.
Biological trace element research
|December 12, 2024
概括
低磁血症影响了近四分之一的原发性甲状腺功能障碍症 (PHPT) 患者. 这种情况与骨质疏松症的更高风险有关,这表明PHPT的更严重形式.
科学领域:
- 内分泌学 在内分泌学.
- 腎臟病學 (nephrology) 是一種醫學.
- 骨的新陈代谢 骨的新陈代谢
背景情况:
- 初级甲状腺功能障碍症 (PHPT) 与矿物质不平衡有关,包括低磁血和低血.
- 在PHPT患者中低磁性血的临床意义仍未得到充分研究.
- 了解这些关联对于管理PHPT并发症至关重要.
研究的目的:
- 在大量PHPT患者中确定低磁性血的患病率.
- 调查低磁血症和常见的PHPT并发症,如骨质疏松症和结石之间的关联.
- 在PHPT中识别与低磁性血症相关的因素.
主要方法:
- 一项全国性的,以人口为基础的回顾性研究,利用土耳其卫生部国家电子数据库 (E-nabız) 的匿名数据.
- 使用国际疾病统计分类和相关健康问题 (ICD) -10代码 (E21) 识别PHPT患者.
- 对96,337名PHPT患者的人口统计数据,实验室值和并发症 (骨质疏松症,结石) 患病率的分析.
主要成果:
- 在PHPT患者中,低磁性血的患病率为23.783%.
- 患有低磁血症的患者显示骨质疏松症的发生频率明显更高 (45.435%与38.541%,p < 0.0001).
- 在低磁性和正常磁性PHPT患者之间没有观察到结石频率的显著差异.
结论:
- 大约四分之一的PHPT患者患有低磁血症.
- 在PHPT中,低磁血可能表明更严重的疾病表型,并与骨质疏松症的风险增加有关.
- 诸如骨质疏松症,高血症,较低的EGFR,较高的PTH水平和晚年等因素与PHPT中的低磁性血症有显著的关联.
相关概念视频
Skeleton and Calcium Homeostasis
4.4K
Calcium is not only the most abundant mineral in bone but also the most abundant mineral in the human body. Calcium ions are needed for bone mineralization, tooth health, heart rate regulation and strength of contraction, blood coagulation, the contraction of smooth and skeletal muscle cells, and the regulation of nerve impulse conduction. The average calcium level in the blood is about 10 mg/dL. When the body cannot maintain this level, a person will experience hypo or hypercalcemia.
4.4K
The Parathyroid Glands
1.9K
The two pairs of parathyroid glands embedded within the posterior surface of the thyroid gland are restricted by a dense capsule around them. These glands comprise two distinct cell populations—parathyroid oxyphil and parathyroid principal cells- pivotal in calcium homeostasis.
Oxyphil cells, whose functions remain elusive, emerge during late puberty, adding a layer of complexity to the parathyroid gland's intricacies. In contrast, principal parathyroid cells undertake a vital role by...
Oxyphil cells, whose functions remain elusive, emerge during late puberty, adding a layer of complexity to the parathyroid gland's intricacies. In contrast, principal parathyroid cells undertake a vital role by...
1.9K
Hormones and Bone Tissue
2.6K
The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
2.6K
Roles of Electrolytes: Calcium and Phosphate
162
Calcium and phosphate are essential electrolytes in the human body, with calcium being the most abundant mineral. Around 99% of the body's calcium is stored in the skeleton and teeth, forming a crystal lattice of mineral salts in combination with phosphates. Calcium plays crucial roles in various bodily functions such as blood clotting, neurotransmitter release, muscle tone maintenance, and nervous and muscle tissue excitability.
The calcium concentration in blood plasma is primarily...
The calcium concentration in blood plasma is primarily...
162
Major Hormones and Their Functions
324
Hormones, the biochemical messengers produced by endocrine glands, are pivotal in regulating bodily functions and maintaining homeostasis. Each hormone's balance is crucial; imbalances can lead to significant physiological disruptions. Major hormones include oxytocin, cortisol, epinephrine, estrogen, testosterone, thyroxine, growth hormone, insulin, and glucagon.
Oxytocin, produced in the hypothalamus and released by the pituitary gland, plays a role in social bonding, childbirth, and...
Oxytocin, produced in the hypothalamus and released by the pituitary gland, plays a role in social bonding, childbirth, and...
324
Synthesis and Functions of Calcitonin
1.6K
Calcitonin, a vital polypeptide hormone, regulates calcium levels within body fluids. It is released by the parafollicular cells, also known as C cells, situated in the follicular epithelium of the thyroid gland. Calcitonin responds to fluctuations in blood calcium levels and the influence of gastrointestinal hormones like gastrin and cholecystokinin.
The exact mechanisms by which calcitonin operates in calcium homeostasis remain elusive, but its significance is evident in several vital...
The exact mechanisms by which calcitonin operates in calcium homeostasis remain elusive, but its significance is evident in several vital...
1.6K


