偏头痛中头痛横向性和MRI上白质超强度的半球分布之间的关联
Adam S Sprouse Blum1, Samual K Zenger2, Andrew H Nguyen2
1University of Vermont, Burlington, VT, USA. Adam.Sprouse-Blum@uvmhealth.org.
Journal of neurology
|December 12, 2024
概括
与右侧头痛患者相比,偏头痛患者的左侧头痛患者在两个大脑半球中表现出更大的白质强度 (WMHs) 负担. 这一发现突显了头痛横向性和脑MRI标志物之间的潜在联系.
科学领域:
- 神经学 神经学
- 神经成像是一种神经成像.
- 偏头痛研究 偏头痛研究
背景情况:
- 大脑白质高强度 (WMHs) 是MRI可见的病变,与微血管疾病有关.
- 在偏头痛患者中,WMH的发生率是偏头痛患者的四倍,但其意义尚不清楚.
研究的目的:
- 调查偏头痛中头痛横向性与大脑MRI上半球白质超强度 (WMHs) 的分布之间的联系.
- 为了确定偏头痛中典型的左侧或右侧头痛是否与MRI上的WMH的特定模式相关.
主要方法:
- 横截面研究评估脑MRI的偏头痛患者与一致的左侧或右侧头痛.
- WMH的位置由盲目审稿人记录下来.
- 统计分析包括千平方,威尔科克森等级和,波松回归和多重回归模型,以评估关联和对混因素的控制.
主要成果:
- 左侧头痛患者更有可能患高血压,更不可能吸烟.
- 在患有左侧头痛的患者中,观察到WMH的总体负担显著增加 (9.8对6.2;p < 0.001).
- 左侧头痛独立地与左侧 (5.1对3.3;p < 0.001) 和右侧 (4.7对3.0;p < 0.001) 脑半球的WMHs增加以及更高的周周结膜Fazekas得分 (p = 0.033) 相关.
结论:
- 偏头痛患者经历典型的左侧头痛,双边表现出更大的白质超强度 (WMHs) 负担.
- 在患有左侧头痛的患者中,也发现了更高的周周结膜Fazekas得分.
- 头痛横向性仍然是半球WMH分布的重要预测因素,即使经过对临床因素的调整.
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