含有tizanidine的内鼻三甲基基托桑涂层乳液作为治疗的脑向治疗:配方,优化和药物动力学评估

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Mohammed H Elkomy1, Omnia M Hendawy2, Randa Mohammed Zaki3,4

  • 1Department of Pharmaceutics, College of Pharmacy, Jouf University, 72341, Sakaka, Saudi Arabia.

Drug delivery and translational research
|December 12, 2024
PubMed
概括

这项研究开发了鼻内提扎尼丁HCl (TZN) 乳液,以改善用于治疗的大脑输送. 与口服TZN相比,新配方显著提高了TZN在大脑和血中的生物可用性.

关键词:
基托桑是一种酸盐.乳化剂是一种乳化剂.鼻腔内输送是指鼻腔内输送.药理动力学 药理动力学的情况是Spasticity.提桑尼丁 (Tizanidine) 是一种类药物.

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