涉及新陈代谢的药物相互作用与传统中国药物在心血管疾病
Ren-Jong Liang1,2, Shu-Hao Hsu3, Tien-Yu Chang3
1Medical Supplies and Maintenance, Hualien Armed Forces General Hospital, Hualien, Taiwan, Republic of China.
Journal of food and drug analysis
|December 12, 2024
概括
传统中医药 (TCM) 与常规药物一起使用可能导致草药相互作用 (HDIs). 本综述检查了55个体内HDI,重点关注心血管疾病治疗及其机制.
科学领域:
- 药理学 药理学是指药理学的学科.
- 综合医学是一个整体的医学.
- 药物新陈代谢 药物新陈代谢
背景情况:
- 草药,特别是传统中医 (TCM),因其治疗效果而得到全球认可.
- 同时使用TCM和药品需要了解草药相互作用 (HDIs).
- 药物代谢酶 (cytochrome P450,UDP-glucuronosyltransferase) 和运输体是HDIs中的关键参与者.
研究的目的:
- 审查有关草药相互作用 (HDIs) 的体内研究.
- 专注于与心血管疾病 (CVD) 治疗相关的 HDI.
- 探索特定TCM的药理动力学 (PK) 和药理动力学 (PD) 影响.
主要方法:
- 对草药相互作用的体内研究进行系统审查.
- 分析了55个已记录的HDI.
- 对所选TCM的PK/PD概况及其对药物代谢的影响进行检查.
主要成果:
- 总结了55种草药相互作用 (HDIs) 的潜在机制.
- 讨论了丹申,人参,金科,申迈注射,申迈-桑,舒-金-霍-谢伊-坦和武楚-尤-坦的PK/PD影响.
- 在TCM使用中确定了显著的HDI的决定因素.
结论:
- 草药相互作用 (HDIs) 显著影响心血管疾病 (CVD) 药物治疗.
- 了解TCM组成和PK/PD对于管理HDI至关重要.
- 仔细考虑HDI对于安全有效的综合医疗保健至关重要.
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