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β细胞KATP的损失降低了胰岛素分泌和Trpm5表达的Ca2+敏感性

Nathaniel W York1,2, Zihan Yan3, Anna B Osipovich4

  • 1Center for the Investigation of Membrane Excitability Diseases, Washington University School of Medicine, St. Louis, MO.

Diabetes
|December 12, 2024
PubMed
概括

在先天性高胰岛素症中,对ATP敏感 (KATP) 通道的损失导致矛盾的胰岛素低分泌. 这种交叉的解释是胰岛素分泌的右转依赖,而不是改变的胰岛素含量.

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