在198名275名学生中,环境颗粒物和潜伏结核病感染之间的关联
Zhongqi Li1,2, Zhan Wang3, Peng Lu1
1Department of Chronic Communicable Disease, Center for Disease Control and Prevention of Jiangsu Province, Nanjing, China.
Journal of global health
|December 12, 2024
概括
暴露于室外颗粒物 (PM) 与潜在结核病感染 (LTBI) 的风险增加有关. 减少空气污染可能有助于降低全球结核病负担.
科学领域:
- 环境健康 环境健康
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 室外颗粒物 (PM) 与肺结核风险之间的关系已经确立,但其与潜在肺结核感染 (LTBI) 的关联仍然不清楚.
- 长期结核病是严重的公共卫生问题,特别是在结核病流行率高和空气污染严重的地区.
研究的目的:
- 调查环境PM度与中国东部学生中发展LTBI的风险之间的关联.
- 使用大规模流行病学研究量化颗粒暴露对LTBI风险的影响.
主要方法:
- 分析了来自中国东部68所中学 (2018-2021) 的198275名学生.
- 收集了空气污染物度 (PM10和PM2.5) 和气象因素的数据.
- 一般化添加剂模型 (GAM) 用于评估PM水平与LTBI风险之间的关系,考虑到延迟效应长达三年.
主要成果:
- 在环境PM度和LTBI风险之间发现了显著的正相关性.
- 对于每增加1μg/m3的PM10,LTBI风险增加了0.82%至0.90% (滞后效应).
- 对于每增加1μg/m3的PM2.5,LTBI风险增加了0.91%至1.32% (滞后效应).
结论:
- 室外PM度升高与潜伏结核病感染风险增加有关.
- 减轻环境空气污染可能是减少全球结核病负担的关键策略,特别是在面临高LTBI率和污染水平的发展中国家.
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