诱导GLP-1受体激素诱导的尤斯塔希管功能障碍:耳鼻喉学不良事件的数据库和系统审查
Kaitlynne Y Pak1, Raffaello M Cutri, Wasiq Nadeem
1Cedars-Sinai Medical Center, Division of Otolaryngology-Head and Neck Surgery, Los Angeles, CA.
类似葡萄糖类-1受体激动剂 (GLP-1RA) 与流动性尤斯塔希管功能障碍 (PETD) 有关. 临床医生应监测使用这些减肥药物的患者的耳朵相关副作用.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 内分泌学 在内分泌学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 葡萄糖类-1受体激动剂 (GLP-1RA) 越来越多地用于肥胖管理.
- 关于GLP-1RA使用对耳鼻喉学影响的研究有限.
研究的目的:
- 调查GLP-1RA与欧斯塔基管功能障碍 (ETD) 之间的关联,特别是状ETD (PETD).
- 为了识别与GLP-1RA治疗相关的潜在耳部不良事件.
主要方法:
- 案例审查,文献审查,以及对FDA不良事件报告系统 (FAERS) 数据库的分析.
- 按照PRISMA指南进行系统审查,以确定相关研究.
主要成果:
- 在GLP-1 RA使用后观察到自声声和听觉充满的病例,证实ET散体的损失.
- 在97,237个总体事件中,FAERS数据显示了958个耳学不良事件 (0.99%).
- 杜拉古化物具有最多的潜在ETD相关的AE (417);exenatide显示的比例最高 (1.52%).
- 系统性审查确定了10项符合纳入标准的研究;常见的耳学副作用包括鼻炎,鼻炎和头.
结论:
- 这项研究报告了GLP-1RA和PETD之间的第一次关联.
- 该机制与减肥手术后观察到的快速减肥诱导的PETD相一致.
- 临床医生应警患者使用GLP-1RA减肥的耳鼻喉学副作用,特别是PETD.
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