大麻使用和心脏移植清单:临床医师实践的调查
Onyedika J Ilonze1, Shannon M Knapp1, Yelena Chernyak2
1Division of Cardiovascular Medicine, Indiana University, Indianapolis, IN, United States of America.
PloS one
|December 12, 2024
概括
医疗保健提供者在评估心脏移植的患者中使用大麻方面存在重大分歧. 合法化状态会影响人们对医用大麻的可接受使用频率和移植中心政策的看法.
科学领域:
- 心脏病学 心脏病学
- 移植医学 移植医学
- 药理学 药理学是指药理学的学科.
背景情况:
- 对于列出使用大麻的心脏移植候选人,没有确定的指导方针.
- 大麻使用很普遍,其对心脏移植资格的影响尚不清楚.
研究的目的:
- 调查临床医生关于他们在心力衰竭患者中使用大麻的知识和实践模式,这些患者被转诊进行心脏移植.
- 根据各州大麻合法性的意见,识别不同意见的差异.
主要方法:
- 一项基于网络的调查分发给了140名临床医生 (心脏病学家,外科医生,药剂师,高级实践提供者,协调员).
- 回答被分析并根据大麻在受访者所在州的合法或非法情况进行分组.
- 进行了统计分析,以比较小组对关键问题的答案.
主要成果:
- 在大麻合法化州的受访者更有可能接受更高的使用频率,然后在取消患者的心脏移植资格之前 (p=0.0330).
- 法律小组中的大多数人认为,经过验证的查问卷可以评估资格 (p=0.0111),他们的中心的政策涉及医用大麻使用 (p=0.0001).
- 相比之下,非法群体中的大多数人报告说,他们的计划不允许处方大麻使用 (p<0.0001).
结论:
- 临床实践和有关心脏移植候选人的大麻使用的知识存在显著的异质性.
- 临床医生通常同意验证的查工具的实用性,并建议在上市之前进行6个月的戒断期.
- 需要标准化的指导方针来解决大麻在心脏移植评估中的使用问题.
相关概念视频
01:18Cardiovascular Drugs: Classification based on Therapeutic Indications
2.0K
Cardiovascular diseases, encompassing a range of conditions, can significantly affect the heart's operations and the overall circulatory system. These conditions impair the heart's ability to pump blood, leading to a deficit in oxygen supply to crucial organs. Anomalies in the heart's electrical system, known as arrhythmias, can cause heartbeats to accelerate or slow down. Usually, heart rates increase during physical activity and decrease while resting or sleeping. However,...
2.0K
01:22Heart Failure Drugs: β-Blockers
316
β-adrenergic antagonists, commonly known as β-blockers, block the effects of sympathetic neurotransmitters such as noradrenaline (NA) and adrenaline (ADR). They have several beneficial effects in heart failure treatment. They reduce heart rate, the force of contraction, and cardiac muscle relaxation. They also slow the atrial-ventricular conduction rate and raise the threshold for arrhythmias. The concentration of β-blockers determines their effects on bronchodilation,...
316
01:20Exercise and Cardiovascular Response
734
Exercise significantly impacts cardiovascular response, which is crucial for understanding patient health and designing effective treatment plans.
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...
734
01:24Tissue Transplantation
338
Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
338
01:28Imaging Studies for Cardiovascular System V: CT
3
Cardiac computed tomography (CT) scanning is an advanced cardiac imaging technique that utilizes CT technology, with or without intravenous (IV) contrast, to produce accurate cross-sectional virtual slices of specific areas of the heart, coronary circulation, and major blood vessels such as the aorta, pulmonary veins, and arteries. The computer processes these slices to generate three-dimensional images. Multidetector CT (MDCT) is a rapid form of CT scanning that captures multiple slices...
3
01:21Chemotherapy-Induced Nausea and Vomiting: Cannabinoids
201
Tetrahydrocannabinol (THC) is a phytocannabinoid that primarily interacts with the CB1 receptor, a type of G protein-coupled receptor (GPCR) predominantly in and around the chemoreceptor trigger zone (CTZ) and emetic center. THC also blocks the serotonin receptor activity in the dorsal vagal complex (DVC) by inhibiting serotonin release. THC exerts its anti-emetic effects through these interactions, which are beneficial for patients undergoing chemotherapy.
Two synthetic agonists of THC,...
Two synthetic agonists of THC,...
201