转基因大豆对Sprague-Dawley大鼠生理变量和肠道微生物群的影响
Elham Ashrafi-Dehkordi1,2, Abdolvahab Alborzi1, Gholamreza Pouladfar1
1Clinical Microbiology Research Center, Nemazee Hospital, Shiraz University of Medical Sciences, Shiraz, Iran.
PloS one
|December 12, 2024
概括
这项研究发现,食用转基因大豆并没有显著改变老鼠的体重,血液标志物或肠道细菌. 然而,建议进一步研究肠道微生物群的抗生素耐药性.
科学领域:
- 农业科学 农业科学
- 毒理学 毒理学 毒理学
- 微生物学 微生物学
背景情况:
- 转基因大豆在食品和料中广泛使用.
- 评估转基因食品的安全性,包括它们对肠道微生物群和抗生素耐药性的影响,至关重要.
研究的目的:
- 评估高转基因大豆饮食对斯普拉格-道利大鼠的生理和微生物学影响.
- 为了比较转基因大豆与非转基因大豆对肠道微生物群和抗生素耐药性的影响.
主要方法:
- 两组老鼠被用转基因或非转基因大豆养120天.
- 分析了体重,血液学和血清生物化学.
- 量化PCR (q-PCR) 用于检测总细菌和特定的人与老鼠共享的细菌.
- 进行了抗生素分析以评估抗生素耐药性.
主要成果:
- 在转基因和非转基因大豆组之间,没有观察到体重,血液学或血清生物化学的显著变化.
- 转基因大豆的消费没有显著影响总细菌或特定肠道细菌群 (Bifidobacterium,Clostridium perfringens,Escherichia coli,Lactobacillus,Bacteroides-Prevotella) 的丰富性.
- 虽然大肠杆菌的耐药性保持不变,但转基因大豆的消费导致E. faecalis中与非转基因组相比,红色素耐药性降低.
结论:
- 在大鼠中,食用70%的转基因大豆并没有引起不良生理影响或改变肠道微生物群的组成.
- 观察到的E. faecalis抗生素耐药性的变化需要进一步调查转基因食品消费对肠道微生物群抗生素耐药性概况的潜在影响.
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