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内静脉贝瓦齐祖马布用于治疗冠状腺血栓瘤

Hassan E Elkayal^1,2, Mandeep S Sagoo^1,3, Guy S Negretti¹

¹Ocular Oncology Service, Moorfields Eye Hospital, London, United Kingdom.

Retina (Philadelphia, Pa.)

|December 12, 2024

概括

室内注射贝瓦西祖马布在缓解与胆道血管瘤相关的脑下液方面表现出有限的有效性. 往往需要进行进一步的治疗,这表明贝瓦齐祖马布不太可能成为这种疾病的首要治疗方法.

科学领域:

眼科医生眼科眼科
医疗视网膜医学视网膜
眼睛的血管瘤

背景情况:

周围的冠状动脉瘤可以导致显著的视力损伤,由于相关的下液 (SRF) 和内液.
对于这些瘤的排泄性变化,有效的治疗策略对于视觉保存至关重要.

研究的目的:

评估内贝瓦西祖马布 (IVB) 在治疗有界胆道血管瘤患者的SRF和内液的疗效.
评估IVB对视觉敏度,患者报告的症状和视网膜液水平的影响.

主要方法:

追溯性对9名患有有界限的胸腔血管瘤的患者进行了回顾,这些患者接受了至少3次IVB注射.
对最佳校正视敏度 (BCVA),SRF,视内液和中央子场厚度 (CST) 的变化进行分析.
评估额外治疗后的结果,如光动力学疗法 (PDT) 或放射治疗.

主要成果:

IVB治疗没有显著改善BCVA (中位数6/19至6/24,P=0.41) 或减少CST (中位数466至447微米,P=0.11).
在三分之一的患者中,只观察到SRF的部分减少;没有一个患者实现了完全的解决.
随后的救援治疗 (PDT或放射治疗) 导致CST显著下降 (中位数为470至249微米,P=0.01),但BCVA变化没有统计学意义 (中位数为6/60至6/12,P=0.63).

结论:

静脉内贝瓦西祖马布作为排泄性环形冠状动脉瘤的独立治疗方法的疗效有限.
救援疗法经常是必要的,以管理液体积累和改善解剖结果.
对这些瘤的最佳治疗模式进行进一步的研究是有必要的.

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