1985年至2021年丹麦肌痛性严重性发病率的变化:一项基于全国人口的全国性研究
Josefine Jul Jarbæk Nielsen1, Lotte Levison1, Henning Andersen1
1From the Department of Neurology, Aarhus University Hospital, Denmark.
Neurology
|December 12, 2024
概括
1985年至2021年间,肌痛性骨髓灰质炎 (MG) 的发病率显著增加,特别是在老年人中. 这种MG率的上升在研究的最近几年是最明显的.
科学领域:
- 神经学 神经学
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 之前关于肌痛性骨髓灰质炎 (MG) 发病率的研究已经产生了不一致的结果.
- 了解MG发病率的时间趋势对于公共卫生规划和资源分配至关重要.
研究的目的:
- 为了确定36年 (1985-2021) 的肌痛性骨髓灰质炎发病率 (IRs).
- 为了识别不同年龄组和随着时间的推移MG发病率的趋势.
主要方法:
- 全国基于人口的研究,使用丹麦国家患者登记 (1985-2021年).
- 包括年龄在18岁以上,初级MG诊断的患者.
- 分类为早期发病 (≤50),晚发病 (>50≤65) 和非常晚发病 (>65) 的年龄组.
- 按性别和时间段计算和分层MG IR,并进行灵敏度分析.
主要成果:
- 确定了2,110名MG患者;整体MGIR为每10万人/年1.4.
- 早期发病的MG IR保持稳定 (0.7每10万人年).
- 晚发症和非常晚发症的MG IR随着时间的推移显著增加,发病率比率 (IRR) 分别为1.9和2.2.
结论:
- 总体而言,MG发病率从1985年至2021年增加,与欧洲趋势一致.
- 在研究期间的后几年,MG发病率的增长最为显著.
- 这种发病率的上升主要是由于晚发症和非常晚发症严重肌痛性肌痛症的增加.
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