宫通道区域与残疾的关联以及多发性硬化症患者的进展
Neus Mongay-Ochoa1, Deborah Pareto1, Manel Alberich1
1From the Multiple Sclerosis Centre of Catalonia (Cemcat) & Neurology Department (N.M.-O., P.C.-M., N.B., A.V.-J., M.T., X.M., J.S.-G.), and Section of Neuroradiology (D.P., M.A., C.A., À.R.), Department of Radiology (IDI), Vall Hebron University Hospital, Barcelona; Neuroimaging Research Unit (P.V., M.M., A.M., P.P., M.A.R., M.F.), Division of Neuroscience, Neurology Unit, and Neurorehabilitation Unit (M.M., M.F.), IRCCS San Raffaele Scientific Institute, Milan, Italy; Multiple Sclerosis Center (MSC) (C.G., C.Z.), Department of Neurology, Neurocenter of Southern Switzerland, Ente Ospedaliero Cantonale; Faculty of Biomedical Sciences (C.G., C.Z.), Università della Svizzera Italiana (USI), Lugano, Switzerland; Faculty of Brain Sciences (F.B.), University College London Queen Square Institute of Neurology, University College London; National Institute for Health Research (F.B.), University College London Hospitals Biomedical Research Centre, United Kingdom; MS Center Amsterdam (F.B., M.M.S., E.M.M.S.), Vrije Universiteit Amsterdam, Amsterdam Neuroscience, Amsterdam UMC location VUmc, the Netherlands; Clinic of Neurology (A. Gallo, A.B.), and MRI Research Center SUN-FISM (A. Gallo, A.B.), Second University of Naples, Italy; Queen Square MS Centre (O.C., F.D.A., M.C.Y.), Department of Neuroinflammation, UCL Queen Square Institute of Neurology, Faculty of Brain Sciences, University College London; National Institute for Health Research (O.C., F.D.A.), Biomedical Research Centre, University College London Hospitals; Nuffield Department of Clinical Neurosciences (J.P., L.M.), Oxford, United Kingdom; Department of Neurology (A. Gass, P.E.), Mannheim Center of Translational Neurosciences (MCTN), Medical Faculty Mannheim, Heidelberg University; Institute of Neuroradiology (C.L., B.B.), St. Josef-Hospital Bochum, Ruhr University Bochum, Germany; Vita-Salute San Raffaele University (P.P., M.A.R., M.F.); Neurology Unit (P.P., M.A.R., M.F.), and Neuropshysiology Service (M.F.), IRCCS San Raffaele Scientific Institute, Milan, Italy.
脊髓储备,以宫通道面积 (CCaA) 衡量,与多发性硬化症 (MS) 的身体残疾有关. 渐进性多发性硬化症患者的CCaA较小,这表明脊髓储备减少有助于残疾.
科学领域:
- 神经学 神经学
- 放射学 放射学是一门学科.
- 神经免疫学 神经免疫学
背景情况:
- 大脑储备可以防止多发性硬化症 (MS) 的认知障碍.
- 脊髓储备的假设是为了防止MS患者的身体残疾.
- 宫运河区域 (CCaA) 被提议作为脊髓储备的代理.
研究的目的:
- 为了研究CCaA作为脊髓储备的代理在多中心性MS队列.
- 评估CCaA与身体残疾及其进展的关联.
主要方法:
- 对MS患者 (PwMS) 和健康对照 (HCs) 的回顾性,多中心,纵向研究.
- 基线3D T1加权的宫MRI以估计CCaA在C2/C3和C3/C4水平.
- 分析各组之间的CCaA差异,以及与扩展残疾状况量表 (EDSS) 分数和残疾进展的关联.
主要成果:
- 与HC和复发性MS (PwRMS) 患者相比,进展性MS (PwPMS) 患者的CCaA在C2/C3和C3/C4显著较小.
- 在C3/C4的CCaA与基线EDSS分数有显著的关联.
- 在5年随访后临床恶化后的PwMS具有较小的基线CCaA.
结论:
- CCaA与MS的基线残疾和临床恶化有关,支持脊髓储备的概念.
- 脊髓储备减少,由较小的CCaA表示,可能是渐进性MS的特征.
- 通过CCaA评估的脊髓储备可能是一个新的成像标志物,用于了解MS的身体残疾.
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