根据年龄和性别,亚临床甲状腺功能障碍与心血管风险因素之间的关联
Oliver Baretella1,2, Manuel R Blum1,2, Nazanin Abolhassani1,3
1Institute of Primary Health Care (BIHAM), University of Bern, 3012 Bern, Switzerland.
The Journal of clinical endocrinology and metabolism
|December 12, 2024
概括
亚临床甲状腺功能障碍 (ScTD) 与心血管风险因素 (cvRFs) 类似于甲状腺功能良好的个体. 观察到的血压和LDL胆固醇的差异太小,无法解释ScTD.
科学领域:
- 内分泌学 在内分泌学.
- 心血管医学 心血管医学
- 流行病学 流行病学
背景情况:
- 亚临床甲状腺功能障碍 (ScTD),包括亚临床甲状腺功能障碍 (SHypo) 和亚临床甲状腺功能障碍 (SHyper),与心血管事件风险增加有关.
- 了解SCTD和心血管风险因素 (cvRFs) 之间的关系对于风险分层和管理至关重要.
研究的目的:
- 调查SCTD与关键cvRF之间的关联,包括血压,脂质概况和高灵敏性C反应蛋白 (hs-CRP).
- 通过年龄和性别分层检查这些协会.
主要方法:
- 在甲状腺研究协作中,分析了来自大型前性队列研究的汇总数据.
- 包括18至103岁的参与者,根据TSH和FT4水平分为SHypo,SHyper和euthyroid组.
- 对cvRFs的评估:血压 (BP),脂质水平 (总,HDL,LDL胆固醇,甘油三) 和hs-CRP.
主要成果:
- 这项研究包括69,006名参与者;5.4%的参与者有Shypo,5.0%的参与者有Shyper.
- 在SCTD组和euthyroid参与者之间没有观察到系统性和透气性血压,脂质水平或hs-CRP的显著差异,除了少数例外.
- 患有SHyper的女性有较低的透析血压,而患有SHyper的男性则有较低的收缩血压. 与非甲状腺患者相比,Shyper患者的LDL胆固醇水平也较低.
结论:
- 患有SCTD的个体的cvRFs在很大程度上类似于euthyroid个体的cvRF.
- 观察到的cvRF差异很小,不太可能解释之前报告的与ScTD相关的心血管风险增加.
- 可能需要进一步的研究来阐明SCTD中心血管风险背后的机制.
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