腹腔大动脉动脉瘤的几何和局部壁厚度使用血管内超声波
Floor Fasen1, Daniek A C van Aarle1, Arjen van der Horst2
1Photoacoustics and Ultrasound Laboratory Eindhoven (PULS/e), Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, 5600, The Netherlands; The Department of Vascular Surgery, Catharina Hospital, Eindhoven, 5602, The Netherlands; Image Guided Therapy Devices, Royal Philips, Best, 5684, The Netherlands.
Computers in biology and medicine
|December 12, 2024
概括
使用血管内超声波 (IVUS) 地图化局部腹腔大动脉瘤 (AAA) 壁厚度为患者提供了新的破裂风险特异标记. 这种方法克服了测量区域厚度的挑战,改善了AAA评估.
科学领域:
- 生物医学工程 生物医学工程
- 医疗成像医学成像
- 心血管研究研究心血管研究
背景情况:
- 目前的腹腔大动脉瘤 (AAA) 治疗依赖于大动脉直径,缺乏患者特有的破裂风险标志物.
- 区域大动脉壁厚度是一个潜在的破裂风险指标,但很难以非侵入性方式测量.
- 现有的成像模式 (CT,MRI,US) 在准确评估局部AAA壁厚方面面临挑战.
研究的目的:
- 开发和验证一种方法来绘制局部变化的AAA壁厚,使用血管内超声波 (IVUS).
- 建立一个新的ex vivo数据集,用于培训和验证AAA壁厚测量技术.
- 为了证明IVUS在体内应用的详细AAA几何和墙壁厚度映射.
主要方法:
- 一个U-net模型被训练在一个新的猪,幻影和模拟的大动脉的ex vivo数据集上,并与地面真相数据进行模拟.
- 血管内超声波 (IVUS) 用于获取数据来绘制AAA壁厚的数据.
- 使用诸如子相似系数 (DSC) 和豪斯多夫距离 (HD) 等细分指标来评估U-net模型的性能.
主要成果:
- U-net模型在墙壁细分方面与地面真相取得了良好的一致性 (DSC = 0.86,HD = 0.97 mm).
- 对墙壁厚度和几何图的分析证实了识别AAA墙壁厚度变化的能力.
- 在体内患者的数据表明,成功地对患病的大动脉壁进行了细分,并测量了不同区域的厚度.
结论:
- 使用IVUS绘制本地AAA墙壁厚的地图是可行的,并提供了详细的几何洞察.
- 这种技术可以测量区域不同的墙壁厚度,这是评估破裂风险的关键因素.
- 开发的方法有可能提高对AAA墙壁特性的理解,并改善破裂风险预测.
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