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灰质结构变化在异常性眼睛快速运动睡眠行为障碍:一个基于voxel的元分析

Xi Wang¹, Yuming Li², Boyi Li¹

¹Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan, China.

|December 12, 2024

概括

异常性快速眼动睡眠行为障碍 (iRBD) 显示大脑灰质体积的变化,包括额头和部区域的减少和小脑和丘脑的增加. 这些发现可能表明,在α-synucleinopathies中早期的神经退行.

科学领域:

神经科学是一个神经科学.
神经学神经学
放射学放射学是一门学科.

背景情况:

异形眼神快速运动睡眠行为障碍 (iRBD) 是α-synucleinopathies的关键早期指标.
之前对iRBD的神经成像研究显示了关于大脑结构的不一致结果.
了解iRBD中的结构性大脑变化对于早期诊断和干预至关重要.

研究的目的:

系统地审查和元分析基于声素的形态测量 (VBM) 研究.
研究与健康对照组相比,iRBD患者的灰质体积 (GMV) 变化.
在iRBD中识别结构性大脑异常的一致模式.

主要方法:

系统审查和voxel-wise元分析.
利用基于种子的d绘图 (AES-SDM) 的异型效应尺寸版本.
包括11项研究,包括341名iRBD患者和288名健康对照.

主要成果:

在双边上额前回,直回,右极,右尾状和右嗅觉皮层观察到GMV的减少.
在双边小脑和丘脑中发现的GMV增加,以及左上尾环.
在敏感性分析中,这些发现是强有力的.

结论:

在iRBD中,结构性大脑异常可能是认知和感觉运动缺陷的基础.
这些发现有助于理解α-synucleinopathies中早期神经退行症状.
在iRBD中灰质体积的变化为预发性神经退行提供了洞察力.

关键词:

灰色物质体积,灰色物质体积.异常性眼睛快速运动睡眠行为障碍睡眠行为障碍进行元分析分析.签名差分映射的不同映射.基于voxel的形态测量方法

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