在晚期黑色素瘤患者中,使用免疫检查点抑制剂进行长期疾病控制后的结果

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Published on: February 8, 2018

Eleanor E Handel¹, Janet McKeown², Joe Wei³

¹Crown Princess Mary Cancer Centre, Westmead Hospital, Sydney, NSW, Australia.

European journal of cancer (Oxford, England : 1990)

|December 12, 2024

概括

晚期黑色素瘤的长期免疫检查点抑制剂 (ICI) 治疗具有较低的晚期复发和死亡风险. 许多获得持久反应的患者可以被认为是治愈的,这可能指导未来的后续策略.

科学领域:

在瘤学瘤学.
免疫学免疫学免疫学
黑色素瘤研究黑色素瘤研究

背景情况:

免疫检查点抑制剂 (ICI) 在晚期黑色素瘤中诱导持久反应,在某些患者中有可能治愈.
关于黑色素瘤ICI治疗后晚期复发和结果的数据有限.
了解长期疾病控制对于优化患者管理至关重要.

研究的目的:

研究ICI长期反应的晚期黑色素瘤患者晚期复发的风险,特征和结果.
分析ICI治疗后持续控制疾病的患者的疾病进展和生存模式.

主要方法:

对567名接受ICI治疗的晚期黑色素瘤患者的回顾性分析,将长期控制定义为在3年内没有后续治疗.
根据3年内疾病进展情况对队列进行分类.
评估复发模式,管理策略和生存结果.

主要成果:

3年后的后续进展发生在7.7%没有早期进展的患者中,而早期进展的患者中为22%.
晚期进展的预测因素包括不完全的放射性反应和3年内先前的进展.
总体死亡率很低 (5.6%),只有1.4%的死亡归因于黑色素瘤.

结论:

晚期黑色素瘤患者通过ICI实现长期疾病控制,晚期进展和死亡的风险较低.
很大一部分长期ICI响应者可能会被治愈.
这些发现可以为ICI治疗中晚期黑色素瘤患者的随访频率和持续时间提供信息.

关键词:

检查点抑制剂检查点抑制剂免疫治疗是一种免疫疗法.黑色素瘤是一种黑色素瘤.幸存的生存方式

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