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关于自身免疫性甲状腺疾病及其与女性生育能力的复杂相互作用的审查
Lindsay Carafone1, Alex J Knutson2, Benjamin J Gigliotti1
1Department of Medicine, University of Rochester School of Medicine & Dentistry, Rochester, New York.
Seminars in reproductive medicine
|December 12, 2024
概括
甲状腺自身免疫性疾病,如哈西莫托病.
科学领域:
- 生殖内分泌学 生殖内分泌学
- 免疫学 免疫学 免疫学
- 孕产妇和胎儿医学 孕产妇和胎儿医学
背景情况:
- 哈西莫托甲状腺炎和格雷夫斯病是生殖年龄妇女常见的自身免疫甲状腺疾病.
- 这些情况会影响女性的生育能力和母胎健康.
- 甲状腺功能障碍 (高或低甲状腺症) 影响下丘脑-垂体-卵巢轴,生殖功能和胎儿发育.
研究的目的:
- 审查自身免疫性甲状腺疾病与女性生育能力之间的复杂关系.
- 讨论甲状腺功能障碍对生殖结果和母胎健康的影响.
- 评估甲状腺子临床疾病在生育中的作用和围绕治疗的争议.
主要方法:
- 关于自身免疫性甲状腺疾病,生育能力和怀孕结果的研究文献综述.
- 对甲状腺功能障碍和甲状腺功能障碍对生殖系统的影响的分析.
- 检查自身免疫对生育能力和流产风险的影响.
主要成果:
- 显而易见的和亚临床的甲状腺功能障碍都会对生育和怀孕产生负面影响.
- 自免疫本身可能会增加流产风险,尽管机制不清楚,数据各不相同.
- 利沃甲状腺素治疗未被证明是有效的,以减轻甲状腺抗体的甲状腺功能良好的妇女的分娩或流产风险.
结论:
- 自身免疫性甲状腺疾病显著影响女性生殖健康和母胎关系.
- 虽然显而易见的甲状腺功能障碍需要治疗,但其在亚临床疾病和生育能力方面的作用仍然存在争议.
- 需要进一步的研究来澄清生育年龄妇女这些疾病的机制和最佳管理策略.
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