年轻成年人非综合性动脉病变的性别和年龄差异
George Bcharah1, Christine E Firth1, Merna M Abdou1
1Department of Cardiovascular Medicine, Phoenix, Arizona, 85054.
The American journal of cardiology
|December 12, 2024
概括
男性在晚年经历大血管动脉瘤和并发症,而女性更早出现中型血管动脉瘤和多部位问题. 未确定的遗传因素可能在动脉病变中的这些基于性别的差异中起作用.
科学领域:
- 血管生物学和医学 血管生物学和医学
- 遗传学和基因组学 在
- 流行病学 流行病学
背景情况:
- 大多数动脉瘤是偶尔发生的,与连接组织疾病无关.
- 之前的研究没有广泛详细介绍跨性别和年龄组的非综合性动脉病变,特别是在年轻人群中.
- 了解这些模式对于有针对性的预防和治疗策略至关重要.
研究的目的:
- 调查和比较不同性别和年龄组的非综合性动脉病变和相关并发症的患病率和表现.
- 在60岁或更年轻的个体中,确定动脉瘤位置,剖析风险和多部位参与的性别特异性模式.
- 在血管疾病的呈现中探索潜在的年龄和性别相互作用.
主要方法:
- 分析了梅奥诊所麻布布DNA测序研究中的84,496名患者的数据,不包括已知的血管综合征患者.
- 包括909名60岁或更年轻的患者,按性别分层和五个年龄组 (18-60岁).
- 动脉病变和并发症的几率和患病率的比较,包括重血管化,中风,剖析和死亡.
主要成果:
- 女性 (68.0%) 更容易患上动脉/脑动脉瘤 (55.2%对31.6%),而男性患上更多的胸部动脉瘤 (50.9%对21.8%) 和腹腔大动脉动脉瘤 (7.22%对2.59%).
- 患有状动脉瘤和带/脑动脉瘤的男性的剖析率较高 (分别为58.14%和21.49%和45.65%和30.79%).
- 妇女更有可能患有多部位动脉瘤 (16.34%vs12.03%),两种性别的36-45岁的剖析率达到峰值,但男性在较年长的年龄组有更多的并发症,女性在较年轻的年龄组.
结论:
- 男人更容易患大血管动脉瘤和晚年生命中的并发症.
- 妇女更频繁地经历中血管动脉瘤,早期并发症和多部位动脉瘤.
- 潜在的未确定的遗传因素可能会影响这些观察到的动脉病变中的基于性别的模式.
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