不同步行能力的外周动脉疾病患者的肌肉组织氧化:一项探索性研究
Gisela Maria Pontes Przybysz1, Patrícia Paulino Geisel1, Isabella de Oliveira Nascimento1
1Graduate Program in Rehabilitation Sciences, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
周围动脉疾病 (PAD) 损害了由于血液流动受限而导致的行走能力. 牛腿肌中的缺血耐药时间是了解PAD患者的行走限制的关键.
科学领域:
- 血管医学 血管医学
- 运动生理学 运动生理学
- 生物医学工程 生物医学工程
背景情况:
- 周围动脉疾病 (PAD) 由于血液流量受到限制,大大降低了行走能力.
- 影响PAD患者走路能力的外周机制仍然不完全理解.
- 这项研究研究了PAD患者与行走能力相关的组织氧化和肌肉新陈代谢.
研究的目的:
- 在具有不同步行能力的PAD个体之间比较组织氧化和肌肉代谢.
- 确定解释PAD患者步行距离差异的关键变量.
- 阐明PAD中微血管功能和运动表现之间的关系.
主要方法:
- 患有PAD的成年人接受近红外光谱学 (NIRS) 测试,以评估胃半腹肌的微血管功能.
- 在动脉堵塞和跑步机测试期间进行了NIRS测量.
- 根据步行距离将参与者分成三分之一;用于分析的是ANOVA和线性回归.
主要成果:
- 在行走能力组之间没有观察到基线或三角形StO2的显著差异.
- 较高的复氧化率,高血中的StO2,到最低的StO2的时间,以及缺血阻力时间在最高行走能力的第三者中被注意到.
- 缺血耐药时间是步行距离的最强预测因素 (调整R2 = 0.83).
结论:
- 在PAD中提高行走性能与更好的动态反应与缺血有关.
- 微血管,内皮和肌肉功能障碍是限制PAD行走能力的关键因素.
- 缺血耐药时间成为PAD患者功能状态的关键指标.
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