运动减轻了自然衰老老鼠的认知衰退,通过调节Notch介导的自信号传递
Dandan Chen1, Yuan Guo2, Meng Zhang3
1College of Sports Medicine, Wuhan Sports University, Wuhan 430079, China; College of Physical Education, Guangxi University of Science and Technology, Liuzhou 545000, China.
Brain research
|December 12, 2024
概括
运动,包括有氧和力量训练,可以对抗大脑衰老. 它通过增强Notch信号和自来促进老老鼠的神经发生和认知功能.
科学领域:
- 神经科学是一个神经科学.
- 衰老研究研究 衰老研究
- 运动生理学 运动生理学
背景情况:
- 痕信号对于神经发生是至关重要的,但随着年龄和神经退行性疾病的增长而下降.
- 运动是对认知衰退的一种有希望的干预措施,但它对与衰老相关的神经发生的影响尚不清楚.
- 自然衰老的老鼠表现出认知缺陷和神经生成的减少.
研究的目的:
- 调查运动干预措施是否可以缓解自然衰老老鼠的认知衰退.
- 为了确定运动是否调节神经发生和老化大脑中的Notch信号通路.
- 为了比较有氧运动,力量运动和综合运动对大脑衰老的影响.
主要方法:
- 21个月大的老鼠经历了12周的有氧运动,力量运动或综合运动.
- 用莫里斯水迷宫评估认知功能.
- 河马神经发生,Notch信号和自标志物通过免疫光学,qRT-PCR和西部斑点分析.
主要成果:
- 老鼠表现出认知能力下降,粉样蛋白前体蛋白 (APP) 和粉样β (Aβ) 积累增加,神经发生学标志物 (DCX,Ki67,GFAP) 减少.
- 在老老鼠的海马体中,痕信号和自显著下调.
- 所有运动类型都提高了Notch信号,自蛋白 (LC3,Beclin1,p62),并改善了空间学习和记忆.
结论:
- 运动干预措施有效地减轻大鼠的大脑衰老.
- 运动可以调节Notch信号和自,促进海马神经发生.
- 运动可以改善老鼠的认知功能和空间记忆.
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