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可溶性CTLA-4 - 在癌症中基于CTLA-4的检查点免疫疗法中的混因素

Parviz Azimnasab-Sorkhabi1, Maryam Soltani-Asl1, Musab Bouhajra2

  • 1Department of Surgery, School of Veterinary Medicine and Animal Sciences, University of Sao Paulo, Sao Paulo, Brazil; Pelotonia Institute for Immuno-Oncology and Division of Medical Oncology, Department of Internal Medicine, Wexner Medical Center, The Ohio State University, Columbus, OH, USA.

Immunology letters
|December 12, 2024
PubMed
概括

可溶性细胞毒性T淋巴细胞相关抗原4 (sCTLA-4) 可能阻碍抗CTLA-4癌症疗法. 这项研究探讨了sCTLA-4在瘤微环境 (TME) 中的抑制作用.

关键词:
在 CTLA-4 中.在CTLA-4异构体中.免疫疗法 癌症 免疫疗法sCTLA-4的使用情况.

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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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