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CCL5-CCR5轴在微质激活中的作用,导致术后认知功能障碍

Yuanyuan An¹, Yu Yao², Huan Liu²

¹Department of Anesthesiology, Nanjing Drum Tower Clinical College of Xuzhou Medical University, Nanjing, China; Department of Anesthesiology, Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese Medicine, Nanjing, China.

Experimental neurology

|December 12, 2024

概括

用CCR5抗剂MVC准CCL5-CCR5轴可以预防和治疗术后认知功能障碍 (POCD). MVC通过抑制CCR5/CREB/NLRP1通路来缓解神经炎症和认知缺陷.

科学领域:

神经科学是一个神经科学.
免疫学免疫学免疫学
药理学药理学是指药理学的学科.

背景情况:

手术后认知功能障碍 (POCD) 是全身麻醉后的常见并发症.
目前尚不清楚CCL5-CCR5轴在POCD病变发生过程中的作用.
在POCD模型中观察到微质激活和神经炎症.

研究的目的:

调查CCL5-CCR5轴在POCD中的参与.
在POCD模型中评估CCR5抗剂 (MVC) 的治疗潜力.

主要方法:

建立了POCD的动物模型.
测量了CCL5和CCR5水平,微质激活和炎症性细胞因子 (IL-6,IL-1β).
使用MVC (CCR5抗剂) 和666-15 (CREB抑制剂) 来评估对神经炎症,树突性脊柱损失和认知功能的影响.

主要成果:

在POCD模型中观察到CCL5和CCR5水平升高,微质激活,IL-6和IL-1β增加.
MVC治疗减少了神经炎症,防止了树突性脊柱损失,改善了认知缺陷.
通过CREB抑制剂666-15,MVC的有益作用被逆转,这表明CCR5/CREB/NLRP1通路的参与.

结论:

CCL5-CCR5轴在POCD发展中发挥着重要作用.
针对CCL5-CCR5轴,使用像MVC这样的CCR5抗剂,对POCD治疗有希望.
抑制CCR5/CREB/NLRP1通路是预防和治疗POCD的潜在治疗机制.

关键词:

在CCL5-CCR5轴上微质细胞中的微质细胞手术后的认知功能障碍 (POCD)

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