英国无并发性尿路感染的治疗模式和负担:一个回顾性队列研究
Mark H Wilcox1,2, Dave Heaton3, Aruni Mulgirigama4
1Department of Microbiology, University of Leeds, Leeds, UK.
无并发性尿路感染 (UTI) 显著增加医疗保健成本和资源使用. 虽然疾病进展不常见,但43.5%的患者接受非一致的抗微生物治疗,突出了改善患者护理的领域.
科学领域:
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
- 卫生经济学 卫生经济学
背景情况:
- 无并发性尿路感染 (UTI) 是常见的细菌感染的重大负担.
- 了解UTI对疾病进展,治疗坚持和医疗费用的影响,对于有效管理至关重要.
研究的目的:
- 评估UUTI疾病进展的决定因素.
- 评估英格兰的抗菌素处方模式与治疗指南相比.
- 量化与UTI相关的医疗负担和经济成本.
主要方法:
- 一项回顾性队列研究利用了临床实践研究数据链 (CPRD) 和2017年1月至2020年2月的医院情节统计数据.
- 包括12岁以上被诊断患有尿路感染的女性患者,分析疾病进展,治疗一致性,以及医疗资源利用率 (HCRU) 和成本.
- 用1:1匹配的无UTI患者队列进行比较负担分析.
主要成果:
- 需要住院治疗的疾病进展发生在0.2%的患者中,受老年和先前住院等因素的影响.
- 显著比例 (43.5%) 的尿路感染患者接受了与当前指南不一致的抗菌药物治疗.
- 与28天和12个月的随访时间相比,患有尿路感染的患者的全因HCRU和成本相对较高.
结论:
- 无并发性尿路感染 (UTI) 与医疗资源利用率和经济负担显著增加有关.
- 虽然严重的疾病进展是罕见的,但非一致的抗微生物药物处方是普遍存在的,这表明需要遵守指南.
- 这些发现强调了优化尿路感染管理的重要性,以减轻医疗保健成本并改善患者的治疗结果.
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