异常运动诱导的肌肉损伤和炎症与高海拔减压结合在成年人
Frode Gottschalk1,2, Mikael Gennser3, Mattias Günther2
1Division of Environmental Physiology, Swedish Aerospace Physiology Center, KTH Royal Institute of Technology, Stockholm, Sweden.
Physiological reports
|December 12, 2024
概括
奇特的运动会导致肌肉损伤和炎症,增加高海拔暴露期间静脉气栓塞 (VGE) 的风险. 这种高度的生理压力加剧了减压应变和全身炎症.
科学领域:
- 生理学 生理学 生理学
- 航空航天医学 航空航天医学
- 运动科学 运动科学
背景情况:
- 高空暴露可以诱导静脉气栓塞 (VGE).
- 众所周知,异常运动会导致运动诱导的肌肉损伤 (EIMD) 和炎症.
研究的目的:
- 调查异常运动诱导的EIMD和炎症对高海拔诱导的VGE的综合影响.
- 评估先前异常运动在模拟高空暴露期间对生理反应的影响.
主要方法:
- 试验对象经过模拟高空暴露 (90分钟24000英尺) 在异常运动 (ECC) 或没有运动 (控制) 后.
- 使用Eftedal-Brubakk (EB) 尺度测量了VGE负载.
- 在多个时间点分析了肌肉损伤 (肌酸激酶,肌球蛋白) 和炎症 (IL-6,TNF-α,CRP,纤维素原) 的血液标志物.
主要成果:
- 与对照组相比,ECC组的VGE分数 (EB-score) 显著更高.
- 在高空暴露之前和期间,ECC导致肌红蛋白,肌酸酶,IL-6和CRP水平显著增加.
- 在ECC组中肌肉损伤和炎症标志物水平升高与VGE负载和暴露后IL-6增加相关.
结论:
- 奇特的运动诱导的肌肉损伤和随后的炎症与高海拔暴露期间增加的VGE负载有关.
- EIMD和高海拔地区的联合生理压力加剧了减压应变和全身炎症.
- 这些发现强调了在高空作业中考虑暴露前的物理条件的重要性.
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