视觉皮层第5层中的快速突破性内神经元:异质响应特性与thalamocortical连接性有关
Chuyi Su1, Rosangela F Mendes-Platt1, Jose-Manuel Alonso1,2
1Department of Psychological Sciences, University of Connecticut, Storrs, Connecticut.
概括
子视觉皮层第5层的快速升的抑制性内部神经元从LGN直接接收输入,表现出与第4层细胞相似的特性. 其他人则表现出明显的调整,这表明间接途径影响了它们的功能.
科学领域:
- 神经科学是一个神经科学.
- 视觉皮层研究 视觉皮层研究
- 细胞电生理学 细胞电生理学
背景情况:
- 子V1的第4层 (L4) 拥有快速升的GABAergic内部神经元 (SIN),具有强大的LGN输入和特定响应特性.
- 第5层 (L5) 也含有SIN,但它们的特性和皮层连接的理解较少.
研究的目的:
- 在清醒的子中研究L5 SIN的响应特性和乳皮层连接性.
- 为了将L5 SIN与之前描述的L4 SIN进行比较.
- 阐明影响L5 SIN功能的途径.
主要方法:
- 醒着的子 (两性) 的电生理学记录.
- 评估L5 SIN对视觉刺激的响应特性.
- 通过LGN刺激和尖列车的交叉相关性分析thalamocortical连接性.
主要成果:
- 许多L5 SIN从LGN接收强烈,快速的单突触输入,与L4 SIN共享响应特性,位于上L5.5.
- 具有较长LGN突触延迟的L5 SIN显示出更清晰的定向调整,更长的响应延迟和更低的发射率,位于更深的L5.5中.
- 这些差异表明L5 SINs具有不同的功能路径 (直接的LGN与间接的皮质内路径).
结论:
- L5 SINs表现出与其甲状腺皮层输入相关的异质响应特性.
- 直接LGN输入形状L5 SIN与L4 SIN类似.
- 多突触性皮质内通路有助于更深层的L5 SINs的独特特性.
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