喘-COPD的患病率和临床影响在严重喘中重叠
Miho Wakazono1, Hirokazu Kimura1, Ichizo Tsujino1
1Department of Respiratory Medicine, Faculty of Medicine, Hokkaido University, Sapporo, Japan.
概括
喘-COPD重叠 (ACO) 影响大约30%的严重喘患者. 然而,ACO并没有增加严重喘队列中的恶化风险或肺功能下降.
科学领域:
- 呼吸系统医学 呼吸系统医学
- 临床研究 临床研究
- 流行病学 流行病学
背景情况:
- 与喘单独相比,喘-COPD重叠 (ACO) 与症状负担和恶化增加有关.
- 关于严重喘患者中ACO患病率和临床影响的数据有限.
- 了解严重喘的ACO对于有效的患者管理至关重要.
研究的目的:
- 为了确定严重喘患者中ACO的患病率.
- 调查ACO对严重喘恶化率和肺功能下降的临床影响.
主要方法:
- 预计将在30个中心招募127名严重喘患者.
- 使用日本呼吸学会标准对ACO的评估.
- 在ACO和非ACO组之间比较临床特征,3年恶化率和5年FEV1下降.
主要成果:
- 在严重喘中,ACO的患病率为31.5%.
- ACO患者年龄较大,更常见的是男性,喘持续时间较长.
- 两组之间没有观察到恶化率 (62.2% vs. 63.2%) 或年度FEV1下降率 (-39.2毫升/年 vs. -31.2毫升/年) 的显著差异.
结论:
- 在这个队列中,大约30%的严重喘患者表现出ACO.
- 在严重喘中,ACO并未被确定为恶化或FEV1下降的独立风险因素.
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