英国出生体重与慢性阻塞性肺病之间的关联 生物银行:前性队列研究
Pengfei Luo1, Jialiu He2, Xinglin Wan3
1Jiangsu Provincial Center for Disease Control and Prevention, Nanjing, Jiangsu, China.
BMJ open respiratory research
|December 12, 2024
概括
低出生体重与成人患慢性阻塞性肺病 (COPD) 的风险增加有关. 这种关联是非线性的,母亲吸烟会加剧这种风险,特别是在出生时体重低的个体中.
科学领域:
- 呼吸系统医学 呼吸系统医学
- 公共卫生 公共卫生
- 流行病学 流行病学
背景情况:
- 出生体重是成年慢性阻塞性肺病 (COPD) 风险的潜在决定因素.
- 之前关于出生体重和COPD之间的关联的研究已经产生了不确定的结果.
- 本研究使用英国生物银行数据调查出生体重和COPD风险之间的联系.
研究的目的:
- 分析出生体重与患上COPD的风险之间的潜在关联.
- 探索出生体重和COPD风险之间的剂量反应关系.
- 检查与出生体重的共同变量对COPD风险的相互作用和联合影响.
主要方法:
- 对没有基线COPD的英国生物库参与者的前性分析.
- 多变量考克斯回归模型用于计算危险比率 (HR) 和95%置信区间 (CI).
- 限制立方线用于评估剂量反应关系和对相互作用的分层分析.
主要成果:
- 包括251,172名参与者;发现了5,602例COPD病例.
- 最低出生体重五分之一 (<2.86公斤) 与COPD风险增加有关 (HR=1.21).
- 观察到非线性关系:COPD风险下降,然后随着出生体重的增加而增加;与年龄,被动和母亲吸烟的相互作用被确定.
结论:
- 低出生体重与COPD的风险增加有关.
- 出生体重和COPD风险之间存在非线性关联,随着出生体重的增加,风险会下降,然后增加.
- 母亲吸烟与低出生体重有共同影响,进一步增加了COPD风险.
关键词:
慢性慢性肺炎的流行病学
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