离子化集成的智能微针配送平台,用于高效的透皮配送和按需释放胰岛素
Mingwei Peng1, Ziwen Heng1, Dewei Ma1
1Research Institute for Biomaterials, Tech Institute for Advanced Materials Bioinspired Biomedical Materials & Devices Center, College of Materials Science and Engineering, Jiangsu Collaborative Innovation Center for Advanced Inorganic Function Composites, Suqian Advanced Materials Industry Technology Innovation Center, Nanjing Tech University, Nanjing 211800, China.
ACS applied materials & interfaces
|December 12, 2024
概括
这项研究介绍了一种与离子化集成的智能微针平台,用于增强通过皮肤递送胰岛素. 该新系统提供无痛,按需的血糖控制,与以前的方法相比,提高了效率和深度.
科学领域:
- 生物医学工程 生物医学工程
- 材料科学 材料科学 材料科学
- 内分泌学 在内分泌学.
背景情况:
- 无痛,按需通过皮肤输送胰岛素仍然是一个重大挑战.
- 现有的对葡萄糖有反应的智能微针 (MNs) 提供自主胰岛素释放,但其通过皮肤递送效率较低.
- 皮下注射是当前的标准,但缺乏方便性和按需控制.
研究的目的:
- 开发一个与离子泳 (ITP) 集成的智能MN输送平台,以提高通过皮肤输送胰岛素的效率和深度.
- 为MN制造创造一种对葡萄糖有反应的水凝,具有改善的机械性能和导电性.
- 为了证明平台的有效和安全的血糖控制能力.
主要方法:
- 智能MN的制造使用具有葡萄糖反应的乙烯酸水凝,并结合碳纳米管 (CNTs) 形成半互穿透网络.
- 电离泳 (ITP) 与智能MN平台的整合.
- 评估通过皮肤输送胰岛素的效率,输送深度和葡萄糖响应.
主要成果:
- 加强CNT的水凝表现出增强的刚性和导电性.
- ITP 显著提高了通过电解和电泳透过皮肤输送胰岛素的效率和深度.
- 集成ITP的智能MNs平台保持了出色的葡萄糖反应能力,使得随需释放胰岛素.
- 该平台展示了在广泛的尺寸范围内成功通过皮肤传递有效载荷的平台.
结论:
- 集成ITP的智能MNs平台为无痛,方便和按需的透皮胰岛素输送提供了一个有前途的解决方案.
- 这项技术有可能实现持续的血糖控制.
- 开发的平台显示了深层皮肤透和最小侵入性传递各种有效载荷的多功能性.
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