胰岛素耐药性,易受斑块和中风风险在患有动脉狭窄症的患者
Junjie Cao1, Dayong Zhou1, Zhichao Yao1
1The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, No. 26 Daoqian Street, Suzhou, Jiangsu, China.
Scientific reports
|December 12, 2024
概括
通过甘油三糖 (TyG) 指数测量的胰岛素耐药性与动脉狭窄患者中风风险增加有关. 脆弱的斑块部分调解了这种关系,突出了它们在中风风险中的作用.
科学领域:
- 心血管医学 心血管医学
- 代谢综合征研究 代谢综合征研究
- 神经学 神经学
背景情况:
- 胰岛素抵抗 (IR) 与易受损伤的斑块形成和中风风险有关.
- 红外线和脆弱斑块在动脉狭窄 (CAS) 中脑卒中风险中的特定作用需要进一步阐明.
研究的目的:
- 为了研究IR (使用甘油三糖 (TyG) 指数) 和易受损伤的斑块与中风风险在CAS患者之间的关联.
- 探索脆弱斑块在IR和中风风险之间的关系中的调解作用.
主要方法:
- 这项研究包括505名患有动脉狭窄症的患者.
- 通过甘油三-葡萄糖 (TyG) 指数评估胰岛素耐药性.
- 限制立方线 (RCS) 和后勤回归分析了关联;调解分析探讨了间接效应.
主要成果:
- 在TyG指数和中风风险 (P < 0.001) 之间发现了正线性关联.
- 提升的TyG指数和脆弱斑块的存在都是中风事件的重要预测因素.
- 在不同模型中,脆弱斑块介于TyG指数和中风风险之间的关联的11.6%至18.3%.
结论:
- 甘油三糖 (TyG) 指数和脆弱斑块的存在独立地与CAS患者中风风险更高有关.
- 在这个人群中,脆弱斑块在胰岛素抵抗和中风风险之间的联系中发挥着部分调解作用.
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