危急疾病后的神经认知功能障碍的潜在机制:系统性审查
Mark Andonovic1, Holly Morrison2, William Allingham3
1Academic Unit of Anaesthesia, Critical Care and Perioperative Medicine, University of Glasgow, Glasgow, UK.
Anaesthesia
|December 13, 2024
概括
长期认知障碍影响了许多重症幸存者. 机制可能涉及加速的神经退行,炎症和白质变化是常见的因素. 需要进一步的研究来理解这种复杂的情况.
科学领域:
- 神经科学是一个神经科学.
- 关键护理医学 关键护理医学
- 公共卫生 公共卫生
背景情况:
- 认知障碍是影响超过1.5亿人的全球健康问题.
- 严重疾病的幸存者经常经历长期的神经认知功能障碍,其潜在机制不清楚.
研究的目的:
- 系统地审查和综合证据,以分析严重疾病后神经认知功能障碍的潜在机制.
- 引导未来的研究方向,以了解和解决这种后临界疾病并发症.
主要方法:
- 对1974年1月至2023年7月期间发表的研究进行了系统的文献搜索.
- 包括专注于成人重症病幸存者的研究,评估认知障碍,并探索因果机制.
- 研究质量和偏差风险使用纽卡斯尔-太华尺度进行了评估.
主要成果:
- 包括37项涉及4344名患者的研究,其中大多数是单一中心的,样本大小小小.
- 长期认知障碍的患病率在患者中从13%到100%不等.
- 炎症性细胞因子增加和白质过强度是最常见的与认知能力下降相关联的相关报道.
结论:
- 临界后疾病神经认知衰退的病理生理学仍然不完全理解.
- 涉及神经退行性疾病的机制表明潜在的加速衰老过程.
- 大规模研究对于充分阐明严重疾病幸存者神经认知功能障碍的原因至关重要.
更多相关视频
相关概念视频
01:26Aging
37
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
37
01:26Alzheimer's Disease: Overview
447
Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
447