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Updated: Jun 5, 2025

Genetic Analysis of Hereditary Transthyretin Ala97Ser Related Amyloidosis
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Genetic Analysis of Hereditary Transthyretin Ala97Ser Related Amyloidosis

Published on: June 9, 2018

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结构和动态的洞察力,对Ala97Ser在Transthyretin中的胺基基基基因突变

Yu-Chen Feng1, Sashank Agrawal1, Chin-Hao Yang1

  • 1Institute of Atomic and Molecular Sciences, Academia Sinica, No. 1, Sec. 4, Roosevelt Rd., Daan Dist., Taipei, 106319, Taiwan.

Chemistry, an Asian journal
|December 13, 2024
PubMed
概括

该Ala97Ser突变破坏了transthyretin (TTR) 的稳定性,增加了FG循环的灵活性并影响了蛋白质动态. 这种结构变化提供了对TTR粉样体疾病的见解,比如家族性粉样体多神经病.

关键词:
核磁共振的- (H/D) 交换方式进行NMR放松.氨基原蛋白是一种氨基原蛋白.化学交换 化学交换 化学交换转二烯是什么意思

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