在非致命性阿片类药物过量治疗的急诊室患者中,与自杀企图相关的因素
Rachel E Culbreth1, Paul Wax1, Jeffrey Brent2
1American College of Medical Toxicology, Phoenix, Arizona, USA.
Substance use & misuse
|December 13, 2024
概括
试图自杀的阿片类药物过量患者更有可能使用处方阿片类药物,而不是非法药物. 这一发现突出了理解过量使用动机的关键区别.
科学领域:
- 毒理学 毒理学 毒理学
- 紧急医疗 紧急医疗
- 精神病学是一个精神病学.
背景情况:
- 过量服用阿片类药物是一个重大的公共卫生危机.
- 区分自杀企图和无意的过量服用对于适当的患者护理至关重要.
- 影响阿片类药物过量后自杀企图的因素需要进一步调查.
研究的目的:
- 为了确定与阿片类药物过量后出现的患者中自杀企图相关的因素.
- 在这个人群中,要区分自杀企图与无意中过量服用的特征.
主要方法:
- 对因疑似阿片类药物过量而出现在急诊室 (ED) 的患者进行前性观察性研究.
- 对1200多种药物和代谢物的血清样本进行分析.
- 查看图表以确定过量服用的意图,病史/社会史和临床变量.
- 后勤回归分析与自杀企图相关的因素.
主要成果:
- 在1,259名患者中,6.4%被归类为自杀企图.
- 仅处方阿片类药物的使用与无意中过量服用相比,与自杀企图有关 (OR:1.27;95% CI:1.21,1.34).
- 自杀未遂与心肺复苏,输管或ICU入院等医疗干预的可能性增加无关.
结论:
- 自杀未遂占了呈现EDs的阿片类药物过量病例的很大一部分.
- 在这种情况下,处方阿片类药物的使用,而不是非法阿片类药物,是与自杀企图相关的关键因素.
- 这些发现强调了针对处方阿片类药物过量治疗患者的有针对性的干预和心理健康评估的必要性.
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