一个美国的多站点试点项目用于查乙型肝炎表面抗原阳性患者的乙型肝炎D
Maggie Li1,2, Bijou Hunt1, Bindu Balani3
1Sinai Infectious Disease Center, Sinai Chicago, Chicago, Illinois, USA.
Journal of viral hepatitis
|December 13, 2024
概括
在美国,D型肝炎病毒 (HDV) 感染的诊断不足. 一项试点研究发现B型肝炎病毒 (HBV) 阳性患者中HDV阳性率较低 (0.81%的抗体,0.18%的RNA),突出显示查挑战.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 传染性疾病 传染性疾病
- 公共卫生流行病学 流行病学
背景情况:
- 肝炎D病毒 (HDV) 是一种严重的,被忽视的,未被确诊的感染,具有显著的临床影响.
- 全球和美国的HDV流行病学特征仍然不太清楚.
- 有效的查策略对于了解和管理HDV流行率至关重要.
研究的目的:
- 确定美国医疗机构中高乙型肝炎病毒 (HBV) 血清阳性高的HDV的流行率.
- 描述检测出HDV阳性的患者的特征.
- 评估HDV查所涉及的诊断和实验室过程.
主要方法:
- 一个试点项目从2022年8月到2024年4月在八个医疗机构进行.
- 对106,693名患者进行了B型肝炎表面抗原 (HBsAg) 测试,1112名 (1.04%) 患者呈HBsAg阳性.
- 对645个HBsAg阳性样本进行了肝炎D病毒抗体 (HDV Ab) 测试,对阳性病例进行了确认性HDV RNA测试.
主要成果:
- 观察到的整体HBsAg阳性率为1.04%.
- 在HBsAg阳性个体中,HDV Ab阳性为0.81% (9/1112).
- 在2例 (0.18%) 确诊HDVRNA阳性,表明HDV感染活跃.
结论:
- 该研究发现,在试点地区的HBsAg阳性患者中,HDV阳性率较低.
- 不完整的测试和查过程对准确的HDV诊断提出了挑战.
- 进一步的研究是必要的,以了解在美国的HDV的真正负担,并告知实施策略.
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