增加皮肤T细胞淋巴瘤的风险在使用dupilumab治疗无氧性皮肤炎后
Jenna Mandel1, Jaanvi Mehta1, Ramsay Hafer1
1Department of Dermatology and Cutaneous Biology, Thomas Jefferson University, Philadelphia, PA, USA.
Dermatologic therapy
|December 13, 2024
概括
杜比卢马布用于亚托皮炎 (AD) 的使用与皮肤T细胞淋巴瘤 (CTCL) 的风险更高有关. 这种风险在60岁以上的患者和在杜皮卢马布治疗的第一年内最为明显.
科学领域:
- 皮肤病学 皮肤病学
- 在瘤学瘤学.
- 药物监督 药物监督 药物监督
背景情况:
- 报告表明dupilumab和皮肤T细胞淋巴瘤 (CTCL) 之间存在联系.
- 关于这种关联的人口层面数据有限.
- 亚托皮炎 (AD) 是一种常见的炎症性皮肤疾病.
研究的目的:
- 为了确定杜皮卢马布治疗阿尔茨海默症是否会增加CTCL风险.
- 确定患有CTCL发病风险较高的患者子组.
- 评估dupilumab启动和CTCL诊断之间的时间关系.
主要方法:
- 使用TrinetX无标识医疗记录数据库进行回顾性队列研究.
- 包括超过118万名阿兹海默症患者.
- 用杜皮卢马布治疗的患者与接受替代AD治疗的对照组的匹配.
主要成果:
- 杜皮卢马布的使用与CTCL的相对风险增加了4.59倍 (RR = 4.59,95% CI 2.459-8.567,P < 0.0001).
- 超过一半的CTCL病例发生在60岁以上的患者中.
- 大多数dupilumab后的CTCL诊断发生在治疗的第一年内.
结论:
- 对AD的杜皮卢马布治疗与发展CTCL的风险增加有关.
- 在60岁以上的患者和治疗第一年内的患者中,风险明显更高.
- 建议在给特定患者群体处方dupilumab时谨慎使用.
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