在急性轻度缺血性中风患者中,甘油三指数与神经系统早期恶化之间的相关性
Yang Liu1, Zhiye Wang1, Zuonian Zhang1
1Department of Neurology, Nanjing Meishan Hospital, Nanjing, China.
Frontiers in neurology
|December 13, 2024
概括
甘油三糖 (TyG) 指数与急性轻度缺血性中风患者的早期神经系统恶化 (END) 有关. 较高的TyG指数水平表明END的风险增加,这表明它在中风患者风险分层中的使用.
科学领域:
- 神经学 神经学
- 代谢综合征是代谢综合征的一种.
- 心血管研究研究心血管研究
背景情况:
- 甘油三糖 (TyG) 指数是胰岛素耐药性的公认指标.
- 它作为缺血性中风风险的预测因素的作用已经确立,但它与轻度缺血性中风早期神经系统恶化 (END) 的关联需要进一步澄清.
- 了解END的预测因素对于及时干预和改善患者结果至关重要.
研究的目的:
- 调查TyG指数与中国急性轻度缺血性中风患者早期神经病变 (END) 的发生之间的相关性.
- 评估TyG指数作为这种患者群体中END的潜在风险分层工具.
主要方法:
- 对402名急性轻度缺血性中风患者的回顾性分析,这些患者于2020年1月至2022年12月期间入院于南京梅山医院.
- 使用国家卫生研究院中风量表 (NIHSS) 评估中风的严重程度.
- 采用多变量逻辑回归和光滑曲线分析来评估TyG指数和END之间的关联,定义为72小时内NIHSS分数的特定增加.
主要成果:
- 经历了END的患者 (402人中有107人) 与没有END的患者相比,TyG指数水平显著更高 (9.18 ± 0.46对比8.87 ± 0.46,p < 0.001).
- 泰格指数与END独立且正相关 (OR = 3.63,95% CI: 1.75-7.54,p = 0.001).
- 与最低四分位数 (p = 0.008) 患者相比,TyG指数最高四分位数的患者患END的风险增加了2.36倍.
结论:
- 泰格指数表明,与急性轻度缺血性中风的中国患者的早期神经系统恶化存在显著,独立和积极的关联.
- 泰格指数显示,它有可能成为一种有价值的工具,用于在急性轻度缺血性中风后患者的风险分层.
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