在2019年冠状病毒病的康复患者中改变了肠道微生物组
Kyoung Hwa Lee1, Yeong Ouk Kim2,3, So Hee Dho4
1Division of Infectious Diseases, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea.
Frontiers in cellular and infection microbiology
|December 13, 2024
概括
COVID-19显著改变了肠道微生物组,严重程度影响了变化. 在7个月后,微生物组的恢复是不完整的,这表明感染对肠道细菌的持久影响.
科学领域:
- 微生物学 微生物学
- 胃肠病学 胃肠病学
- 传染性疾病 传染性疾病
背景情况:
- 众所周知,新冠肺炎疾病2019 (COVID-19) 会影响各种身体系统.
- 新出现的证据表明,COVID-19对肠道微生物群有重大影响.
研究的目的:
- 调查COVID-19疾病严重程度与肠道微生物组的变化之间的关联.
- 在感染后的七个月内评估便微生物组成的纵向变化.
主要方法:
- 一项多中心,前性的纵向研究,涉及58名COVID-19患者和116名对照人群.
- 使用16S核糖体RNA测序来分析便中的微生物差异.
- 便样本是在早期康复阶段和感染后至少七个月收集的.
主要成果:
- 与对照组相比,COVID-19患者的Eubacteriales和Bifidobacteriales数量减少,Bacteroidales和Burkholderiales数量增加.
- 肠道微生物组的α多样性在COVID-19患者中减少,在7个月后观察到不完全恢复.
- COVID-19的严重程度是影响微生物组合的最重要因素,在考虑到抗生素和年龄后,影响仍然存在.
结论:
- COVID-19 感染导致肠道微生物组合的显著和长期变化.
- 疾病的严重程度是微生物组失调症的程度的一个关键决定因素.
- 需要进一步的研究来探索呼吸道病毒感染和肠道微生物群之间的机制联系.
相关概念视频
01:50What is Monogastric Digestion?
70.6K
The human body contains a monogastric digestive system. In a monogastric digestive system, the stomach only contains one chamber in which it digests food. Several other animal species also have monogastric digestive systems, including pigs, horses, dogs, and birds. This chapter, however, focuses on the human digestive system.
70.6K
01:29Bacterial Flora of the Large Intestine
378
The gut microbiome is formed by a vast and diverse community of bacteria that colonizes our large intestine. These bacteria start residing in the gut from birth and continue diversifying throughout life, influenced by factors such as diet, lifestyle, and stress. The gut bacterial community also includes bacteria from food and those that enter the colon through the anus.
The normal gut flora of the colon plays a critical role in generating essential vitamins such as vitamins K, B5, and B7.
The normal gut flora of the colon plays a critical role in generating essential vitamins such as vitamins K, B5, and B7.
378