在美国成年人中,残留胆固醇和肉症之间的关联
1Department of Orthopaedics, The first people's hospital of Zhaoqing, Zhaoqing, China.
Frontiers in endocrinology
|December 13, 2024
概括
高的残留胆固醇 (RC) 水平与美国成年人患肉症的风险更高有关. 这一发现表明RC可能是评估肉症风险的有用指标.
科学领域:
- 心血管健康 心血管健康
- 代谢障碍 代谢障碍 代谢障碍
- 老年医学 老年医学
背景情况:
- 剩余胆固醇 (RC) 是一种新兴的脂质代谢生物标志物.
- 肌肉衰竭和肉类衰竭之间的关联,一种肌肉质量损失的情况,仍然不清楚.
- 了解这种关系对于识别有风险的个体至关重要.
研究的目的:
- 在美国成年人群中调查残留胆固醇水平和肉症之间的关联.
- 探索潜在的非线性关系,并根据RC.确定肉症的风险值.
- 为了确定RC作为一种潜在的标志性标志物来评估萨尔科佩尼亚.
主要方法:
- 对来自4636名参与者的NHANES 2011-2018数据进行横截面分析.
- 曲率数据的RC的对数转换;评估关联的逻辑回归.
- 限制立方线 (RCS) 和值和技术用于分析非线性效应.
主要成果:
- 在RC水平升高的个体中,sarcopenia的患病率显著更高.
- 在日志RC和麻症 (OR=1.69) 之间观察到正相关性.
- 确定了一个非线性关系,RC=25的值;在这个水平以下观察到风险增加.
结论:
- 升高的残留胆固醇显著与美国成年人中萨科佩尼亚患病率的增加有关.
- 剩余的胆固醇可以作为一种有价值的,新的指标,用于评估肉症的风险.
- 进一步的研究可以探索RC在治疗肉症的临床效用.
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