在怀孕和产后期间1,5无水甘醇,血糖和母乳养之间的关系:试点研究
Marti D Soffer1,2, Kaitlyn E James1,3,4, Michael Callahan5
1Harvard Medical School, Boston, MA.
Journal of the Endocrine Society
|December 13, 2024
概括
在怀孕和产后期间,1,5-二甲基醇 (1,5AG) 水平会下降. 母乳养与较低的1.5AG有关,这表明将其排泄到牛奶中,但1.5AG不是孕妇血糖水平的可靠指标.
科学领域:
- 生殖内分泌学 生殖内分泌学
- 代谢健康 代谢健康
- 临床化学 临床化学
背景情况:
- 高血糖的评估对于孕期和产后的母亲和婴儿健康至关重要.
- 标准的口服葡萄糖耐受性测试 (OGTTs) 是有效的,但对患者造成重大负担.
- 为了改善产科血糖监测,研究其他生物标志物,如1,5-二醇 (1,5AG) 是必不可少的.
研究的目的:
- 为了评估整个妊娠期和产后时期的1,5-二醇 (1,5AG) 水平的变化.
- 为了确定1.5AG水平与已建立的血糖指标之间的关联.
- 探索1.5AG水平与母乳养状态之间的关系.
主要方法:
- 对50名怀孕的参与者和非怀孕的对照进行了长度研究.
- 口服葡萄糖耐受性测试 (OGTTs) 在怀孕和产后期间在多个时间点进行.
- 使用冷血样本测量的1,5-二糖醇 (1,5AG).
- 统计分析包括混合效应线性模型,斯皮尔曼相关性和线性回归.
主要成果:
- 1,5AG水平从怀孕早期到晚期显著下降,并在产后仍然很低.
- 与非孕妇对照组相比,孕妇和产后患者表现出较低的1.5AG水平.
- 在1.5AG水平和血糖指标之间没有发现显著的关联.
- 纯母乳养的个体与配方奶粉养的个体相比,具有明显较低的1.5AG水平.
结论:
- 在怀孕期间,1,5-基醇 (1,5AG) 水平自然下降,并在产后持续存在.
- 哺乳期与1,5AG水平的降低有关,可能是由于排泄到母乳中.
- 1,5AG不是评估孕妇或产后妇女血糖的合适生物标志物.
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