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感染对2型糖尿病患者死亡率的贡献:使用电子记录进行基于人口的队列研究
Iain M Carey1, Julia A Critchley1, Umar A R Chaudhry1
1Population Health Research Institute, St George's, University of London, London, SW17 0RE, United Kingdom.
The Lancet regional health. Europe
|December 13, 2024
概括
患有2型糖尿病 (T2D) 的人面临的感染死亡风险高于没有糖尿病的人. 这项研究揭示了感染负担比以前认可的要大,强调了需要更好的意识和治疗的必要性.
科学领域:
- 糖尿病研究研究 糖尿病研究
- 传染病流行病学 传染病流行病学
- 死亡率研究 死亡率研究
背景情况:
- 患有2型糖尿病 (T2D) 的人对感染的易感性增加.
- 现有的研究可能低估了T2D中感染相关的死亡率,因为依赖于专注于潜在原因的临床编码系统.
研究的目的:
- 调查2015-2019年期间与一般人口相比,T2D患者的特定原因死亡率.
- 专门研究T2D患者感染相关死亡的负担.
主要方法:
- 一项队列研究将509,403名2型糖尿病患者与976,431名无糖尿病患者进行了匹配.
- 用国家相关死亡率数据分析了死亡率数据 (2015-2019年),计算了所有ICD-10章节的感染死亡.
- 考克斯模型用于估计所有原因和特定原因死亡率的危险比率 (HR),并对败血症进行了额外分析.
主要成果:
- 16.8%的2型糖尿病患者死亡,而没有糖尿病的患者死亡率为10.9%.
- 感染是T2D的第三大潜在死亡原因 (13.0%),明显高于之前报告的.
- 在T2D与非糖尿病中所有感染死亡率的HR为1.82,超过所有原因死亡率的HR (1.65).
结论:
- 患有T2D的人比非糖尿病人有更高的感染相关死亡率.
- 在T2D中,感染相关死亡的整体负担是相当大的,并且可能被常规统计数据低估.
- 提高认识,早期诊断和及时治疗感染对于预防T2D患者过早死亡至关重要.
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