多药耐药沙门氏菌的流行病学 Typhi 和 Paratyphi 从便培养物中分离出来
Tito Aloys Ndima Etouke1, Georges Ful Kuh1, Boris Emmanuel Djoumsie Gomseu1
1Department of Biochemistry, University of Dschang, Dschang, Cameroon.
Journal of tropical medicine
|December 13, 2024
概括
由沙门氏菌引起的肠热是一个主要的健康问题,特别是由于抗生素耐药性增加. 这项研究确定了沙门氏菌Typhi和Paratyphi临床分离物中的风险因素和高多药耐药性.
科学领域:
- 微生物学 微生物学
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 肠热是由Salmonella enterica serovars Typhi和Paratyphi引起的,在发展中国家造成了严重的健康负担.
- 越来越多的抗生素耐药沙门氏菌株的流行加剧了疾病控制和治疗的挑战.
研究的目的:
- 为了研究沙门氏菌Typhi和Paratyphi临床分离物的抗生素耐药性模式.
- 为了确定与肠道发烧感染相关的危险因素.
主要方法:
- 一项涉及2020年6月至2021年9月1076名患者的横截面研究.
- 通过面对面采访和问卷收集数据,用于检测沙门氏菌的便样本培养.
- 使用磁盘扩散方法和多变量逻辑回归进行风险因素分析的抗生素耐药性分析.
主要成果:
- 多变量分析揭示了肠热与年轻年龄组的女性,食用贝类,沙拉,水果,蔬菜,冰块和流动商人的食物之间的显著关联.
- 观察到高水平的多药耐药 (MDR) 沙门氏菌,对一线药物 (安培素,氨基醇,co-trimoxazole),诺基诺和第三代素产生耐药性.
- 根据人口统计学和生活方式因素,抵抗模式的差异很大.
结论:
- 该研究强调了研究群体中MDR沙门氏菌Typhi和Paratyphi的出现.
- 特定的饮食习惯和非正式来源的食物/饮料的消费是肠热的重要危险因素.
- 建议进行进一步的大规模研究,以监测喀麦隆各地的MDR沙门氏菌血清病毒.
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