老年人中巴罗反射敏感性和长期痴呆症风险
Yuan Ma1, Yiwen Zhang1, Rikuta Hamaya1,2
1Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA (Y.M., Y.Z., R.H., A.H.).
Hypertension (Dallas, Tex. : 1979)
|December 13, 2024
概括
降低血压调节器巴罗反射灵敏度 (BRS) 与不服用血压药物的老年人患痴呆症风险较高有关. 这一发现表明BRS可能是预防痴呆症的新生物标志物.
科学领域:
- 心血管生理学心血管生理学
- 神经科学是一个神经科学.
- 老年学是一门学科.
背景情况:
- 血压变化升高与痴呆症风险增加有关.
- 巴罗反射灵敏度 (BRS) 的作用在痴呆风险中仍然不清楚,这是一个关键的血压稳定机制.
研究的目的:
- 调查心脏巴罗反射灵敏度 (BRS) 与老年人患痴呆症的风险之间的联系.
- 确定BRS是否是痴呆风险的独立预测因素.
主要方法:
- 心脏BRS测量了1819名来自社区的鹿特丹研究的老年人,使用节拍血压记录.
- 参与者被跟踪发病性痴呆和所有原因死亡率超过14.8年的中位数.
- 经过对平均血压和血压变化进行调整的统计分析.
主要成果:
- 在随访期间,共有421名参与者患上痴呆症.
- 降低BRS显著与痴呆风险增加有关,但仅在不使用抗高血压药物的参与者中 (aHR: 1.60,95%CI: 1.07-2.40).
- 减少BRS也与较高的全因死亡风险有关 (aHR: 1.76,95% CI: 1.32-2.35).
结论:
- 减弱的巴罗反射灵敏度可能会导致高血压相关的脑损伤和痴呆风险.
- BRS可以作为早期痴呆症检测和预防的新生物标志物,特别是在高血压患者中.
- 这些发现凸显了BRS在评估痴呆风险方面超越传统血压测量的重要性.
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