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Updated: Jun 5, 2025

A Model Membrane Platform for Reconstituting Mitochondrial Membrane Dynamics
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A Model Membrane Platform for Reconstituting Mitochondrial Membrane Dynamics

Published on: September 2, 2020

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通过反诱导的空心凝析物的相位分离,以创建生物模拟的无膜隔间

Jianmian Fu1, Bin Wang1, Weiping Zhu1,2

  • 1Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, P. R. China. triyang@ecust.edu.cn.

Journal of materials chemistry. B
|December 13, 2024
PubMed
概括

研究人员使用酸-寡核酸结合物开发了动态无膜. 这些隔间从微滴转变为空洞凝聚物,模仿细胞功能并响应环境pH值变化.

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Mechanisms of Membrane Domain Formation00:59

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Different physical properties of lipids and proteins allow them to localize and form distinct islands or domains in the membrane. Some membrane domains are formed due to protein-protein interactions, whereas others are formed due to the presence of specific lipids such as sphingolipids and sterols—for example, large proteins, such as bacteriorhodopsin, aggregate and create distinct domains.
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Scientists identified the plasma membrane in the 1890s and its principal chemical components (lipids and proteins) by 1915. The model for plasma membrane structure, proposed in 1935 by Hugh Davson and James Danielli, was the first model to be widely accepted in the scientific community. The model was based on the plasma membrane's "railroad track" appearance in early electron micrographs. Davson and Danielli theorized that the plasma membrane's structure resembled a sandwich...
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