托通过调节下丘脑AMPK-mTOR信号通路来调节生长猪的食物摄入量
Juexin Fan1,2, Yuezhou Yao3, Leli Wang1
1Laboratory of Animal Nutritional Physiology and Metabolic Process, Institute of Subtropical Agriculture, Chinese Academy of Science, Changsha, Hunan410125, People's Republic of China.
The British journal of nutrition
|December 13, 2024
概括
食托补充剂通过影响下丘脑和肠道中关键的食欲调节基因和激素来提高猪的食物摄入量. 这项研究澄清了托的含量.
科学领域:
- 动物营养 动物营养
- 分子内分泌学分子内分泌学
- 猪生理学 猪生理学
背景情况:
- 托芬 (Trp) 是一种必需的氨基酸,对动物生长至关重要.
- 目前尚不清楚Trp如何影响猪的食物摄入的确切机制.
- 了解Trp在食欲调节中的作用对于优化生猪生产至关重要.
研究的目的:
- 调查食托补充剂对生长猪的食物摄入的影响.
- 阐明参与猪下丘脑中Trp介导的食欲调节的分子途径.
主要方法:
- 养殖猪的食补充剂含有不同水平的托芬.
- 分析基因表达的甲氧基因 (AgRP) 和无氧基因 (POMC,CART,MC4R) 在下丘脑的因素.
- 测量肠道和血清荷尔蒙水平 (PYY,瘦素受体) 和代谢通路的激活 (氨酸,血,AMPK,mTOR/S6K1).
主要成果:
- 饮食TRP补充剂 (SID Trp:Lys比为0.18-0.20) 显著增加了食物摄入量.
- 在下丘脑中,Trp上调氧化性AgRP和下调氧化性POMC,CART和MC4R基因表达.
- Trp降低了PYY和瘦素受体水平,激活了 kynurenine 和 serotonin 途径,并调节了 AMPK/mTOR 信号级联.
结论:
- 食托补充剂对生长中的猪具有氧化作用.
- Trp调节下丘脑基因表达和肠-大脑信号通路,以刺激食欲.
- 这项研究为开发营养策略提供了见解,以提高猪生产中的料摄入量.
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