红细胞分布宽度与白蛋白比率以及急性肺血栓塞栓症的死亡率
Berrin Zinnet Eraslan1, Sumeyye Kodalak Cengiz1, Ozlem Saniye İçmeli1
1Department of Chest Diseases, University of Health Sciences, Kartal Dr. Lütfi Kırdar City Hospital İstanbul, Turkey.
Biomolecules & biomedicine
|December 13, 2024
概括
红细胞分布宽度 (RDW) /白蛋白比 (RAR) 可以预测肺血栓塞栓症 (PTE) 患者的死亡率. 较高的RAR (≥5.294) 表示显著较短的生存期,表明其预后价值.
科学领域:
- 生物标志物和预测方法
- 心血管医学 心血管医学
- 炎症研究 炎症研究
背景情况:
- 红细胞分布宽度 (RDW) /白蛋白比 (RAR) 是一个新兴的基于炎症的预后生物标志物.
- 关于RAR在患有肺血栓塞栓症 (PTE) 患者的预后价值的研究有限.
研究的目的:
- 评估RDW/白蛋白比率 (RAR) 与被诊断患有肺血栓塞栓症 (PTE) 的患者的死亡率之间的联系.
主要方法:
- 对190名PTE患者 (2017-2023) 的回顾性审查.
- 收集的人口统计数据,并发症,临床发现,RDW,白蛋白,热素,D-二次体和死亡结果.
- 计算RAR并使用ROC分析和Cox回归分析其与临床变量和存活率的相关性.
主要成果:
- 确定了5.294的RAR截止值.
- 患有RAR≥5.294的患者的平均存活时间显著缩短 (16.3个月与35.2个月相比).
- 恶性和RAR是PTE患者生存的独立预测因素.
结论:
- 较高的RDW/白蛋白比率 (RAR) ≥5.294与非大规模PTE的生存率较差有关.
- 在临床环境中,RAR显示出作为PTE管理的有价值的预后标志物的潜力.
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